皱皮木瓜总黄酮镇痛作用的机制分析  

Mechanisms Analysis on the Analgesic Effect of Total Flavonoids Extracted from Chaenomels lagenaria

作　　者：孔劲松[1] 杨兴海[1] 

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《时珍国医国药》2009年第3期549-550,共2页Lishizhen Medicine and Materia Medica Research

基　　金：湖北省教育厅自然科研计划项目(No.2004J001)

摘　　要：目的探讨皱皮木瓜总黄酮(FLC)的镇痛作用及其镇痛机制。方法利用小鼠热板、扭体法模型和兔耳皮下K+渗透外周致痛模型,观察FLC的镇痛作用,并分析与Ca2+的关系。结果FLC不仅具有全身镇痛作用,还具有外周镇痛作用;其全身及外周镇痛作用可被CaC l2拮抗,被EGTA所加强。5%,10%和20%FLC呈浓度依赖性抑制50 mmol.L-1K+诱导蟾酥坐骨神经Ca2+含量增加;10%FLC抑制10-5mmol.L-1NE诱导蟾酥坐骨神经Ca2+含量增加。结论FLC的镇痛作用机理可能与其抑制神经组织钙通道和非神经组织钙通道,减少致痛介质释放等因素有关。Objective To evaluate the analgesic action and its mechanisms of total flavonoids from Chaenomels lagenaria （FLC）. Methods By the hot - plate and twisting body test in mouse and peripheral model of the potassium iontophoretic dolorimotry in rabbit, the analgesic action of FLC and its association with Ca^2＋ was analyzed. Results FLC not only had systematic analgesic effect, but also had peripheral analgesic effect. Analgesic effect of FLC could be antagonized by CaCl2, and enhanced by EGTA. In the experiment of frog,sciatic nerve,5 percent, 10 percent and 20 percent FLC inhibited the increase of calcium ion content evoked by 50 mmol · L^- 1 K^ ＋ in a concentration dependent manner. 10 percent FLC also inhibited the increase of calcium ion con- tent evoked by NE 10^-5 mmol· L^-1. Conclusion FLC has analgesic effect , and analgesic mechanism may be associated with cal- cium channel.

关 键 词：皱皮木瓜总黄酮 钙离子 坐骨神经 镇痛作用 

分 类 号：R284.2[医药卫生—中药学]