低分子肝素对男性冠心病患者骨代谢的影响  

Effect of low molecular heparin in male patients with coronary heart disease of bone metabolism

作　　者：刘俊明[1] 窦清惠[1] 黄文军[1] 谢伟[1] 李科[1] 赵亮[1] 邹琦[1] 王明建[1] 

机构地区：[1]新疆兵团医院内一科

出　　处：《中国骨质疏松杂志》2009年第3期193-196,共4页Chinese Journal of Osteoporosis

摘　　要：目的本研究旨在通过对使用低分子肝素男性冠心病患者骨代谢的影响因素的分析，探讨骨质疏松与低分子肝素的关系，为骨质疏松及冠心病的防治寻找理论依据。方法本组21例冠心病患者来自我院2005年-2008年住院的男性冠心病患者，此组患者病史中1年内曾使用低分子肝素，另根据年龄、体重指数、族别、病史选择21例同期住院的男性冠心病患者但未使用低分子肝素的患者进行配对研究。2组冠心病患者均符合世界卫生组织（WHO）冠心病诊断标准，2组患者均用美国GE公司生产的Lunar型双能X线骨密度仪进行腰椎前后位、左侧股骨近端的BMD测定，体内短期精确度CV值分别L1-4为1．2％；股骨近端为2．0％。又经过专门培训的技术人员专人测定。统计方法：全部数据均采用SPSS15．0软件进行统计分析，根据以往的文献报导，计量资料用x^-±s，进行非配对t检验；计数资料采用卡方检验；组间比较采用率的构成比分析。结果2组年龄、体重指数比及冠心病、骨质疏松危险因素等相比差异均无统计学意义（P〉0．05），具有可比性。2组血清钙、磷及不同部位的骨密度比较，2组钙磷水平无明显差异，治疗组（2．12±0．654）血清钙略低于对照组（2．43±0．653），但无统计学差异（P〉0．05），而血清磷水平平均差异不显著（1．12±0．322，1．31±0．212）；2组腰椎（0．326±0．175，0．713±0．156）及股骨颈（0．295±0．167，0．729±0．201）骨密度比较，治疗组均低于对照组，且有统计学意义（P〈0．05）；进一步分析发现股骨颈骨密度下降较明显，其差异具有统计学意义（P〈0．05）；2组患者股骨颈不同水平骨密度T值结果比较，结果显示：治疗组无论是骨量减低还是骨质疏松患者比例明显高于对照组，在-1～-2．5SD有统计学意义（P〈0．05）。结论低分子肝素可能致�Objective The purpose of this study is to find the relationship between osteoporosis and coronary heart disease by analyzing these dangerous factors on men patients with low molecular heparin with coronary heart disease, to find a theoretical basis about prevention and treatment of coronary heart disease and osteoporosis. Methods This group consisted of 21 male patients with coronary heart disease admitted into our hospital from 2005 - 2008. This group of patients had a history of the use of low molecular heparin in recent years, and the other 21 male patients with coronary heart disease without use of low molecular weight heparin were selected based on age, body mass index, the history of choice over the same period of hospitalization to matched-pairs research for project（s）. Two group patients with coronary heart disease are diagnosed based on the criteria from the World Health Organization （WHO）. BMD of two group patients was measured by dual-energy X-ray absorptiometry made by G. E in U.S. BMD was measured of lumbar of dorsaventral, and the left proximal femur. In vivo shortly term degree of accuracy CV lumbar in 1 to 4 is 1.2% ; accuracy is 2.0%. BMD was measured by the specialist person who was trained for 3 months. And specially trained technicians determined person. Statistics： All data were analyzed by SPSS 15.0 software for statistical analysis, based on previous literature reports, measurement data with x^-± s, non-paired with t test; count data using chi-square test; group to compare the rate of adoption of theconstitution than the analysis. Results The group of patient of age, body mass index and coronary heart disease, osteoporosis risk factors, and so there was no statistically significant difference compared to （P 〉 0.05）, with comparable. 2 Group serum calcium, phosphorus and bone mineral density in different parts of the comparison group 2 had no significant difference in the level of calcium in the treatment group （2.12± 0.654） serum calcium was slightly lower than the co

关 键 词：冠心病 低分子肝素 骨代谢 

分 类 号：R246.1[医药卫生—针灸推拿学]