阿司匹林在磷酸钠缓冲液(0.05mol·L^(-1),pH 6.8±0.05)中测定波长的考察  

Survey of determined wavelength for putting aspirin into phosphate buffer(0.05mol·L^(-1) pH 6.80±0.05)

作　　者：谢友亮 兰福珍 

机构地区：[1]福建省宁德市药品检验所,宁德352100 [2]福建省龙岩市药品检验所,龙岩364000

出　　处：《海峡药学》2009年第1期40-42,共3页Strait Pharmaceutical Journal

摘　　要：目的探索阿司匹林在磷酸钠缓冲液(0.05mol.L-1,pH6.8±0.05)中λmax实际测定值与标准规定出现偏差的原因,并确定λmax真值。方法主要考察不同仪器、批号、pH值、温度、放置时间、水杨酸含量对阿司匹林在磷酸钠缓冲液(0.05mol.L-1,pH6.8±0.05)中λmax的影响;同时,调取历年阿司匹林肠溶片检验原始记录中阿司匹林对照品λmax数值,进行回顾性分析。结果pH变小、阿司匹林中水杨酸含量增高等均可导致λmax红移;本次实验测得阿司匹林在磷酸钠缓冲液(0.05mol.L-1,pH6.8±0.05)中λmax为267.0nm,回顾性分析λmax为266.8nm,实验排除了pH值变小、阿司匹林中水杨酸含量增高等λmax红移因素导致阿司匹林在磷酸钠缓冲液(0.05mol.L-1,pH6.8±0.05)中λmax实际测定值比标准规定大的可能。结论pH变小、阿司匹林中水杨酸含量增高等均可导致λmax红移,而阿司匹林在磷酸钠缓冲液(0.05mol.L-1,pH6.8±0.05)中λmax即测定波长为267nm更妥。OBJECTIVE Exploring the deviated reason for the actual measured value and standard code of λmax for putting aspirin into phosphate buffer （0.05mol·L^-1,pH6.8±0.05）, and confirm the actual value of λmax. METHODS Mainly review the influence on λmax when put aspirin in phosphate buffer （0.05mol·L^-1,pH6.8±0.05） through different instrument, lot number, pH value, temperature, standing time and salicylic content; and meanwhile, taking the value of λmax of aspirin reference substance in the original record of aspirin enteric-coated tablet test throughout the years to review analysis. RESULTS Both of samller pH value and salicylic content increased in aspirin could cause λmax red shift, λmax was 267.0 nm in this test, and λmax Was 266.8 nm in the review survey . This test eliminates the factors that the actual measured value was bigger than the standard for putting aspirin into phosphate buffer （0.05mol·L^-1,pH6.8±0.05）. CONCLUSION Smaller pH value and salicylic content increased in aspirin can cause λmax red shift, while it is better that determined wavelength （λmax） is 267nm for putting aspirin into phosphate buffer （0.05mol·L^-1,pH6.8±0.05）.

关 键 词：阿司匹林 测定波长 λmax 

分 类 号：R927.11[医药卫生—药学]