2型糖尿病病人血清sICAM-1、sVCAM-1与颈动脉粥样硬化的相关性研究  

Relationship between Serum Levels sICAM-1、sVCAM-1 and Carotid Atherosclerosis in Patients with Type 2 Diabetic Mellitus

作　　者：张太阳[1] 熊燕[2] 李淑兵[1] 李勇峰[1] 王克平[1] 张国强[1] 王茜[1] 刘敏[1] 

机构地区：[1]南昌市第二医院内分泌科,南昌330002 [2]南昌大学第二附属医院内分泌科,南昌330006

出　　处：《实用临床医学（江西）》2009年第1期18-21,共4页Practical Clinical Medicine

基　　金：江西省卫生厅科技计划课题(20063085)

摘　　要：目的探讨2型糖尿病(T2DM)病人血清细胞间黏附分子1(sICAM-1)和血管细胞黏附分子1(sVCAM-1)与颈动脉粥样硬化的关系。方法酶联免疫吸附(ELISA)法检测120例T2DM病人(T2DM组),根据超声颈动脉内中膜厚度(IMT)检查结果将120例T2DM病人分为3个亚组:IMT正常组40例、IMT增厚组30例、IMT斑块组50例(又根据超声IMT检查结果分为2小亚组:稳定斑块组36例、不稳定斑块组14例)与58例健康体检者(对照组)血清sICAM-1、sVCAM-1水平,并进行生化指标检测。结果糖尿病组血清sICAM-1、sVCAM-1水平均显著高于对照组(均P<0.05)。IMT增厚组、IMT斑块组血清sICAM-1、sVCAM-1水平均显著高于IMT正常组(均P<0.05),不稳定斑块组显著高于稳定斑块组(P<0.05)。糖尿病组血清sICAM-1、sVCAM-1水平与三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、高敏C反应蛋白(Hs-CRP)均呈正相关(r=0.670、0.665、0.666、0.702、0.678、0.675、0.686、0.704,均P<0.01)。结论T2DM病人血清sICAM-1、sVCAM-1水平与颈动脉粥样硬化程度及斑块稳定性有关,其升高与慢性高血糖、脂代谢紊乱及炎症反应相关。Objective： To explore the relationship between serum levels soluble intercellular cell adhesion molecule-1（sICAM-1）soluble vascular cell adhesion molecule-1 （sVCAM-1）and carotid atherosclerosis in patients with type 2 diabetes mellitus（T2DM）. Methods The serum levels of sICAM-1.sVCAM-1 of 120 patients with T2DM were measured by ELISA and then with Biochemical indicators detections. Based on IMT,DM patients were divided into three groups： IMT normal group（n=40）,IMT thickened group（n=30）,IMT plaque group（n=50）. For the results of IMT,this group was divided into 2 sub groups： stability plaque group, 36 cases; instability plaque group, 14 cases）and healthy controls group（n=58）,and Doppler ultrasound in 120 cases of T2DM and 58 cases of healthy medical examiner（control group）. Results The serum levels of sICAM-1 and sVCAM-1 in T2DM were higher than those in control group（P（0.05, respectively）. Among T2DM patients,the serum levels of sICAM-1 and sVCAM-1 were higher in IMT thickened group and IMT plaque group than in IMT normal group （P〈0.05, respectively）, Furthermore,the serum levels of sICAM-1 and sVCAM-1 in patients with unstable plaques were higher than in those with stable plaques（P（0.05）. The change of serum levels of sICAM-1 and sVCAM-1 was positively correlation with triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, hemoglobin Alc （ HbAlc）, high-sensitive C-Reaction protein （Hs-CRP） [r = 0. 670,0. 665, 0. 666,0. 702,0. 678,0. 675,0. 686,0. 704,P〈0. 01,respectively]. Conclusion Among T2DM patients, the serum levels of sICAM-1 and sVCAM-1 might be related to the extent of carotid atherosclerosis and plaques stability. The elevation of the serum levels of sICAM-1 and sVCAM-1 is correlated with TG, LDL-C, HbAlc and chronic inflammation.

关 键 词：2型糖尿病 SICAM-1 SVCAM-1 颈动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]