哮喘患者外周血转化生长因子β_1与呼吸阻抗关系的研究  

Study on the Relationship between TGF-β_1 in Peripheral Blood and Respiratory Impedance in Asthmatics

作　　者：许萍[1] 周世良[1] 夏武 刘晓静[1] 李平[1] 漆兰[1] 周胜亮[1] 

机构地区：[1]南昌大学第四附属医院呼吸科,南昌330003 [2]九江医学院附属医院呼吸科,江西九江332000

出　　处：《江西医学院学报》2009年第1期23-25,28,共4页Acta Academiae Medicinae Jiangxi

基　　金：江西省卫生厅科技计划项目(20061134)

摘　　要：目的探讨不同程度的支气管哮喘患者血清转化生长因子β1(TGF-β1)的变化及其与脉冲振荡技术(IOS)测定呼吸阻抗各主要指标之间的关系。方法用酶联免疫吸附试验(ELISA)测定56例不同程度的支气管哮喘患者的血清TGF-β1水平,同时作IOS肺功能检测,并设30例健康对照组。结果哮喘组血清TGF-β1浓度较对照组低,中重度组较轻度组低,各组间差异均有显著性(P<0.05或P<0.001);哮喘组呼吸总阻抗(Zrs)、5 Hz和20 Hz黏性阻力(R5、R20),5 Hz与20 Hz时的黏性阻力差(R5-R20)、共振频率(Fres)、中心阻力(Rc)、周边阻力(Rp)与对照组比较均增高,5 Hz振荡频率时的电抗(X5)降低;血清TGF-β1水平与呼吸阻抗指标Zrs、R5、R5-R20、Fres呈显著负相关,与X5呈显著正相关,其中Fres的相关性最为密切,与Rc无相关性。结论哮喘患者血清TGF-β1水平下降与呼吸阻抗的增高和病情严重程度有直接关系,通过血清TGF-β1水平能间接反映哮喘患者气道阻力的变化,可作为支气管哮喘诊断、病情判断的参考指标。Objective To investigate the change of serum TGF-β1 and the relationship between serum TGF-β1 and the main indictors of IOS in different severity asthmatics. Methods Measured TGF-β1 in peripheral blood with ELISA and IOS of 56 cases of asthma and 30 cases of healthy persons. Results The Serum TGF-β1 concentration of asthmatics was lower than that in normal control group. Serum TGF-β1 concentration in the moderate-severe asthmatics group was lower than that in the mild asthmatics group, and the difference was significant（P〈0. 05 or P〈0. 001）; There were significant increases in respiratory impedance （Zrs）, respiratory resistance 5 Hz and 20 Hz（R5, R20 ）, the difference of R5 and R20 （R5 - R20 ）, resonant frequency （Fres）, central resistance （Rc） ,peripheral resistance （Rp） in the asthma group than those in control group. Reactance in 5 Hz （X5）in the asthma group was lower than that in control group; There was a significant negative correlation between the serum TGF-β1 and the main indictors： Zrs, R5, R5- R20, Fres and a significant positive correlation between the serum TGF-β1 and X5. The serum TGF-β1 had the highest correlativity with Fres and no correlation with Rc. Conclusion Serum TGF-β1 level down has direct relation with the increase of lOS and the disease severity and serum TGF-β1 level could indirectly reflect the changes of airway resistance in asthma patients. It could be used as a reference index for diagnosis and judgment of patient＇s condition with asthma.

关 键 词：支气管哮喘 转化生长因子Β1 脉冲振荡技术 呼吸阻抗 

分 类 号：R562.25[医药卫生—呼吸系统]