曲马多预注对全麻苏醒期不良反应的观察  

Effect of Pre-injecting Tramadol on Adverse Reactions in General Anesthesia Awakening Period

作　　者：赵汝有[1] 周胜岐[1] 崔新亮[1] 邵东梅[1] 

机构地区：[1]安徽省蚌埠医学院第二附属医院麻醉科,233040

出　　处：《中华全科医学》2009年第4期353-354,共2页Chinese Journal of General Practice

摘　　要：目的探讨曲马多预注对全麻苏醒期的不良反应和术后不适的预防作用。方法选择ASA I～II级全麻手术患者80例,随机分为观察组(T组,n=40)和对照组(C组,n=40),分别于手术结束前40 min,观察组(T组)给予昂丹司琼4 mg+地塞米松10 mg+曲马多100 mg,对照组(C组)给予昂丹司琼4 mg+地塞米松10 mg。观察两组患者拔管期心血管反应和躁动程度,对术后早期切口疼痛和咽喉痛程度评分。结果拔管期心血管反应发生率从62.5%显著降至20.0%(P<0.01),躁动程度T组较C组明显减轻(P<0.01),术后早期切口疼痛程度发生率中、重度疼痛T组轻于C组,组间比较差异有统计学意义(P<0.01),术后咽喉痛程度T组比C组轻(P<0.01)。结论全麻结束前预注曲马多可有效预防或减轻苏醒拔管期不良反应和术后早期的疼痛。Objective To investigate the preventive effect of pre-injeeting tramadol on the adverse reactions and postoperative discomfort in general anesthesia awakening period. Methods 80 cases undergoing ASA Ⅰ-Ⅱgeneral surgery were randomly di- vided into observation group（ T group, n = 40） and control group（ C group, n = 40） respectively. 40 min before the end of opera- tion, Group T was given Ondansetron 4 mg ＋ Dexamethasone 10 mg ＋ Tramadol 100 mg,while Group C was given Ondansetron 4 mg ＋ Dexamethasone 10 mg. The cardiovascular response and degree of restlessness in the extubation period, and the early inci- sion pain and throat score after the operation were evaluated. Results The incidence of cardiovascular response during extubation period in the group T was 20.0% , and lower significantly than Group C （ 62.5% ） , （ P 〈 0.01 ）. The degree of restlessness was palliative, and the early incision pain and throat score after the operation were mild in group T, the difference between the two groups had statistically significance （ P 〈 0.01 ）. Conclusion The pre-injecting tramadol can prevent effectively the adverse reac- tions and postoperative pains in general anesthesia awakening period.

关 键 词：曲马多 预防 全麻 不良反应 

分 类 号：R614.2[医药卫生—麻醉学]