注射用红花黄色素在健康人体内的药动学  

Study on the pharmacokinetics of intravenous infusion injection of hydroxysafflor yellow A in Chinese healthy volunteers

作　　者：肖芬 杨志福[2] 杨静[2] 田云[2] 乔逸[2] 贾艳艳[2] 文爱东[2] 

机构地区：[1]陕西中医学院药学院,陕西咸阳710000 [2]第四军医大学西京医院药剂科,陕西西安710032

出　　处：《中国医院药学杂志》2009年第6期436-438,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助项目(编号:30672662)

摘　　要：目的:建立人血浆中羟基红花黄色素A(HSYA)高效液相色谱(HPLC)测定法,考察HSYA在健康女性体内单次和多次给药后药动学。方法:12名健康女性受试者第1天单剂量静滴HSYA70mg,第2天起qd,连续6d,给药后用HPLC测定不同时间血药浓度,求得主要药动学参数。结果:单次和多次静滴HSYA在体内过程符合非房室模型,主要药动学参数:Cmax分别为(5.9±1.6)、(7.8±2.4)mg.L-1;tmax分别为(1.17±0.29)、(1.00±0.00)h;AUC0-15分别为(23.2±2.5)、(27.2±7.6)mg.L-1.h;AUC0-∞分别为(23.8±2.8)、(28.6±8.4)mg.L-1.h;t1/2β分别为(2.96±0.23)、(4.4±1.4)h。结论:qd,连续7d,静滴HSYA70mg,药物在体内无蓄积,受试者耐受性良好。OBJECTIVE To study the pharmacokinetics of intravenous infusion injection of hydroxysafflor yellow A（HSYA） at multiple-dose and the determination of HSYA in Chinese healthy volunteers. METHODS The plasma samples of 12 healthy volunteers were collected after injecting 70mg intravenous infusion injection of HSYA once a day for 7 days and were deter mined by HPLC method. RESULTS The main pharmacokinetic parameters of HSYA after injection a sing dose（70mg）and multiple-dose were as follow：Cmax were （5. 9± 1.6）,（7.8±2.4） mg ·L^-1;AUC0-15were （23.2±2.5）,（27.2±7.6） mg ·L^-1; AU0-∞ ,were （23.8±2.8）,（28.6±8.4） mg·L^-1·h;tmax were （1. 17±0.29）,（1.00±0.00）h;t1/ 2β were （2. 96±0.23）,（4.4± 1.4）h. CONCLUSION There are no body cumulation after injecting 70 mg intravenous infusion injection of HSYA once per day for 7 days, the volunteers are safe.

关 键 词：羟基红花黄色素A 高效液相色谱 连续给药 药动学 

分 类 号：R969.1[医药卫生—药理学]