阿克他利缓释片比格犬体内的药物动力学  

Pharmacokinetics of sustained release tablets of actarit in Beagle dogs

作　　者：王秀萍[1] 费瀚雨[2] 张奇[2] 

机构地区：[1]华中科技大学同济医学院附属梨园医院,湖北武汉430077 [2]华中科技大学同济医学院药学院,湖北武汉430030

出　　处：《中国医院药学杂志》2009年第6期438-441,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:建立比格犬血浆中阿克他利浓度的定量分析方法,测定其在犬体内的血药浓度经时过程,评价缓释片的药动学及相对生物利用度。方法:比格犬6只采用双周期交叉给药的实验方法,测定阿克他利在比格犬血浆内的浓度,用DAS2.0程序拟合药物浓度-时间曲线,求算药物动力学参数。结果:阿克他利缓释片和普通片在比格犬体内过程均符合单室一级吸收模型,剂量校正后与普通片相比,阿克他利缓释片tmax,t1/2延长,Cmax降低,平均生物利用度为(108.9±11.5)%。结论:阿克他利缓释片具有明显的缓释特征,生物利用度与市售普通片等效。OBJECFIVE To establish a method for the pharmacokineties and bioavailability study of atarit in Beagle dogs. METHODS 6 dogs were divided into two groups by double crossing method in two weeks. The concentrations of atarit in plasma were determined by HPLC,and pharmacokinetics parameters were calculated by DAS 2.0 program. RESULTS The pharmacokinetics of atarit tablets and atarit sustained release tablets were fitted to one-compartment modle. After dose revised, the resuhs indicated that t and t1/ 2 of atarit sustained release tablets were longer and the Cmax was lower than atarit tablets. The bioavailahilily of atarit sustained release tablets relative to atarit tablets was （108.9 ± 11.5）% . CONCLUSION Atarit sustained release tablets have marked sustained release characters.

关 键 词：药物动力学 生物利用度 高效液相法 阿克他利 缓释片 

分 类 号：R969[医药卫生—药理学]