水氯酊处方优选的试验研究  

Study on formula optimization for Shuilv tincture

作　　者：盛国荣[1] 

机构地区：[1]南通市皮肤病性病防治所,江苏南通226006

出　　处：《中国医院药学杂志》2009年第6期446-449,共4页Chinese Journal of Hospital Pharmacy

基　　金：南通市指令性社会发展科技计划项目(编号:S2007026)

摘　　要：目的:制备治疗脂溢性皮炎的外用制剂水氯酊。方法:采用正交试验设计法考察不同处方的水氯酊对实验性动物的抗炎镇痛作用,根据考察数据设计最优处方。结果:水氯酊的最优处方为1000mL中含水杨酸20g,氯霉素20g,薄荷脑10g,二甲亚砜50mL。结论:正交试验设计法优选水氯酊的处方,方法可行,效果满意。OBJECTIVE To select the best formula for Shuilv tincture of treating seborrheic dermatitis. METHODS Orthogonal experiment was used to study the antiinflammatory and analgesic effects of different formula on experimental animals. The best formula was designed according to the result of these studies. RESULTS The optimized formula was salicylic acid 20 g, chloromycetin 20 g, menthol 10 g, dimetbyl sulfoxide 50 mL per 1 000mL. CONCLUSION The formula is reasonable and proves effective.

关 键 词：正交设计 水氯酊 处方优选 小鼠 镇痛试验 抗炎试验 

分 类 号：R943[医药卫生—药剂学]