新型1,5-苯并硫氮衍生物的合成和晶体结构  

Synthesis and Crystal Structure of Novel Derivatives of 1,5-Benzo[b]thiazepine

作　　者：叶嘉炜[1] 杨春[2] 杨德保[2] 刘方明[1,2] 

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046 [2]杭州师范大学材料与化学化工学院,杭州310036

出　　处：《有机化学》2009年第3期414-419,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.29702007,20162004)资助项目

摘　　要：以β-二甲胺基苯丙酮盐酸盐为原料,经过羟醛缩合,与邻氨基硫酚的环化,最后与氯乙酰氯的[2+2]环加成反应,合成了8种未见文献报道的新化合物,其结构经IR,1H NMR和MS及元素分析确证.利用单晶X射线衍射法测定了化合物4e的晶体结构.Eight title compounds were synthesized by the multi-step reaction using β-dimethylamino- propiophenone hydrochloride as stating materials, followed by aldol condensation, cyclization with o-aminothiophenol, and [2＋2] cycloaddition reaction with chloroacetyl chloride. The structures of these compounds were characterized by ^1H NMR, MS techniques and elemental analysis. Compound 4e was subjected to single crystal X-ray diffraction analysis to determine their structure.

关 键 词：1 5-苯并硫氮杂[艹卓] Β-内酰胺 晶体结构 

分 类 号：O625.7[理学—有机化学]