1-取代哌啶-4-酮肟醚的合成与杀菌活性测定  

Synthesis and Antifungal Activity of 1-Substituted Piperidin-4-one Oxime Ether

作　　者：尹安琴[1] 薛思佳[1] 方治坤[1] 陈龙[1] 胥杨[1] 

机构地区：[1]上海师范大学生命与环境科学学院化学系,上海200234

出　　处：《有机化学》2009年第3期454-458,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20672073);上海市重点学科建设(No.T0402)资助项目

摘　　要：以取代苄胺或苯乙胺为起始原料,依次经Michael加成,Dieckmann缩合,水解脱羧,肟化和醚化等多步反应合成了11个未见文献报道的1-取代哌啶-4-酮肟醚5a～5k.目标化合物的结构经元素分析,IR,1H NMR和MS测定确证.初步杀菌活性测试表明,部分化合物有较好的杀菌活性.Eleven unreported 1-substitutedpiperidin-4-one oxime ethers 5a-5k were synthesized with （un）substituted benzylamines or phenethylamine as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation reactions, oximation and etherification. The structures of all newly synthesized compounds were elucidated and confirmed by elemental analysis, IR, IH NMR and MS techniques. The preliminary antifungal activity tests show that some of the target compounds have good antifungal activities.

关 键 词：1-取代-4-哌啶酮 肟醚 合成 杀菌活性 

分 类 号：TQ450.2[化学工程—农药化工]