水杨醛氨基葡萄糖Schiff碱金属配合物抗菌活性的微量热法研究  

MICROCALORIMETRIC STUDY ON THE ANTIBACTERIAL ACTIVITY OF SALICYLAL GLUCOSAMINE SCHIFF BASE AND ITS METAL COMPLEXES

作　　者：黄在银[1] 冯英[1] 屈松生[1] 

机构地区：[1]武汉大学化学系

出　　处：《华中师范大学学报（自然科学版）》1998年第1期71-73,共3页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金

摘　　要：用微量热法研究了水杨醛氨基葡萄糖席夫碱ＳＧ配体及其金属配合物和金属离子对大肠杆菌的代谢抑制．根据大肠杆菌的生长代谢热谱，计算出细菌在指数生长期的生长速率常数ｋ、传代时间Ｇ、细菌生长抑制率Ｉ和代谢热量Ｑ．结果表明：不同化合物的抗菌活性不同；ＳＧ配体和金属离子形成配合物后其抗菌活性均增强，抗菌活性强弱顺序是：ＳＧ＞Ｃｏ（Ⅲ）ＳＧ＞ＺｎＳＧ＞Ｃｕ（Ⅱ）ＳＧ和Ｚｎ２＋＞Ｃｏ２＋＞Ｃｕ２＋＞Ｎｉ２＋．In this paper, the inhibition of four kinds of Schiff base complex and four kinds metal ion on E.Coli have been studied by the method of microcalorimetry. The results show that different kind of compounds has different effect on E.Coli , it follows the sequence of SG>Co(Ⅲ)SG>ZnSG>Cu(Ⅱ)SG and Zn 2+ >Co 2+ >Cu 2+ >Ni 2+ . Under the action of different compounds, their metabolic thermograms are different, the mechanisms of their actions are also different.

关 键 词：水杨醛氨基 葡萄糖 金属配合物 席夫碱 抗菌活性 

分 类 号：O625.632[理学—有机化学] O641.4[理学—化学]