黄芩苷固体脂质纳米粒体外释放研究  

In Vitro Release of Baicalin Solid Lipid Nanoparticles

作　　者：黄义[1,2] 李新中[1,2] 雷鹏[1,2] 刘韶[1,2] 许利敏[1,2] 

机构地区：[1]中南大学湘雅医院,长沙市410008 [2]中南大学药学院,长沙市410013

出　　处：《中国药房》2009年第9期646-647,共2页China Pharmacy

基　　金：湖南省科技厅科技计划一般项目(05SK3002)

摘　　要：目的:研究黄芩苷固体脂质纳米粒的体外释药规律。方法:采用动态透析技术研究黄芩苷固体脂质纳米粒的体外释药性能,并用高效液相色谱法测定黄芩苷含量,以累积释药百分率进行不同模型的拟合。结果:黄芩苷固体脂质纳米粒的释放曲线符合Hixon-crowell方程,t≈3h。结论:黄芩苷固体脂质纳米粒具有良好的缓释作用。OBJECTIVE： To study the in vitro release profile of baicalin solid lipid nanoparticles. METHODS： The in vitro release profile of baicalin solid lipid nanoparticles was studied using dynamic dialysis technology; the content of baicalin was determined by HPLC, and the fitting of different models were performed based on the accumulative drug release percent- ages. RESULTS： The release curve of baicalin solid lipid nanoparticles was in line with the Hixon - crowell equation, with t1/2≈3 h. CONCLUSION： Baicalin solid lipid nanoparticles had satisfactory sustained release efficacy.

关 键 词：黄芩苷 固体脂质纳米粒 体外释放 

分 类 号：R283.69[医药卫生—中药学] R969.1[医药卫生—中医学]