A new drug carrier:Magnetite nanoparticles coated with amphiphilic block copolymer  

作　　者：CHANG Yu BAI YunPeng TENG Bao LiZhaoLong 

机构地区：[1]Department of Chemistry, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Science Bulletin》2009年第7期1190-1196,共7页

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 50573040);Major State Basic Research Development Program of China (Grant No. 2007CB935601)

摘　　要：This paper reports on the synthesis and characterization of 4 nm magnetite nanoparticles coated with amphiphilic block copolymers of poly(ethyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PEMA- b-PHEMA) by surface-initiated atom transfer radical polymerization (ATRP), which can act as new potential carriers for hydrophobic targeted drug delivery. Vibrating sample magnetometer analysis indi-cated that the magnetite nanoparticles were superparamagnetic at room temperature. Thermogravim-etric analysis (TGA) was applied to studying the property of surface of magnetite nanoparticles, and the surface density of macromolecules was calculated. The grafting density of oleic acid, BrMPA and PEMA was 5.8, 3.9, 0.16 chain/nm2 respectively, which indicates that the initiation efficiency decreases due to the influence of large space of oleic acid molecules. In vitro progesterone and (-)-isoproterenol hy-drochloride release in phosphate buffered saline (PBS) at pH 7.0 and 37℃ was conducted in order to demonstrate the function of drug loading and release. The results showed that the amount of drug carried into the core-shell Fe3O4@PEMA-b-PHEMA depends on the length of hydrophobic segment of block copolymer. The release of progesterone (37% after 22 h in our previous work) was compared with the release of (-)-isoproterenol hydrochloride (80% after 50 min), demonstrating that the strong hy-drophobic interaction between hydrophobic segment and drug can effectively control the release of hydrophobic drugs.This paper reports on the synthesis and characterization of 4 nm magnetite nanoparticles coated with amphiphilic block copolymers of poly（ethyl methacrylate）-b-poly（2-hydroxyethyl methacrylate） （PEMA- b-PHEMA） by surface-initiated atom transfer radical polymerization （ATRP）, which can act as new potential carriers for hydrophobic targeted drug delivery. Vibrating sample magnetometer analysis indicated that the magnetite nanoparticles were superparamagnetic at room temperature. Thermogravimetric analysis （TGA） was applied to studying the property of surface of magnetite nanoparticles, and the surface density of macromolecules was calculated. The grafting density of oleic acid, BrMPA and PEMA was 5.8, 3.9, 0.16 chain/nm^2 respectively, which indicates that the initiation efficiency decreases due to the influence of large space of oleic acid molecules. In vitro progesterone and （-）-isoproterenol hydrochloride release in phosphate buffered saline （PBS） at pH 7.0 and 37℃ was conducted in order to demonstrate the function of drug loading and release. The results showed that the amount of drug carried into the core-shell Fe3O4@PEMA-b-PHEMA depends on the length of hydrophobic segment of block copolymer. The release of progesterone （37% after 22 h in our previous work） was compared with the release of （-）-isoproterenol hydrochloride （80% after 50 min）, demonstrating that the strong hydrophobic interaction between hydrophobic segment and drug can effectively control the release of hydrophobic drugs.

关 键 词：双亲嵌段共聚物 纳米涂层 药物载体 磁铁矿 原子转移自由基聚合 甲基丙烯酸乙酯 盐酸异丙肾上腺素 磁性纳米粒子 

分 类 号：TQ460.4[化学工程—制药化工] O631[理学—高分子化学]