支气管哮喘急性发作期患者血清干细胞因子水平测定及意义  

Measurement and significance of SCF in serum of patients with acute exacerbation of bronchial asthma

作　　者：包爱华[1] 王静[1] 张辉[1] 付晓敏[1] 王焕琴[1] 李娟[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《山东医药》2009年第3期7-9,共3页Shandong Medical Journal

摘　　要：目的探讨哮喘急性发作期患者血清干细胞因子(SCF)水平变化及意义。方法将40例支气管哮喘急性发作患者按病情严重程度分为轻、中、重、危重组,采用ELISA法检测各组治疗前后血清SCF水平,同时与10例正常人血清SCF水平作对照。结果中度、重度及危重组治疗前血清SCF水平明显高于对照组(P均<0.001),治疗后均有明显下降;重度及危重组治疗后血清SCF明显高于中度及轻度组(P均<0.01)。结论血清SCF的水平可能与哮喘急性发作的严重程度有关;其在哮喘发病及病情判断中可能起重要作用。Objective To investigate the change and significance of stem cell factor （SCF） level in serum of patients with acute exacerbation of bronchial asthma. Methods 40 patients with acute exacerbation of bronchial asthma were divided into 4 groups with severity, and the serum SCF level of which were measured respectively by ELLISA. 10 normal subjects as control. Results Serum SCF levels in moderate, severe and critical group were significantly higher than that in control group（P 〈0.01 ）, and decreased after treatment respectively. The serum SCF levels of post-treatment patients in severe and critical groups were higher than that in the slight and moderated groups（P 〈 0.01 ）. Conclusion The level of serum SCF maybe related to the severity of asthma attack. SCF plays an important role in both pathogenesis and determination of asthma.

关 键 词：干细胞因子 血清 哮喘 急性发作 

分 类 号：R562.2[医药卫生—呼吸系统]