《伤寒论》甘草量效探微  

Dose-response patterns of Radix Glycyrrhizae in Shanghan Lun

作　　者：杨学[1] 孔祥亮[2] 岳小强[1] 

机构地区：[1]第二军医大学中医系经典著作教研室,上海200433 [2]上海中医药大学基础医学院伤寒论教研室,上海201203

出　　处：《中西医结合学报》2009年第3期268-272,共5页Journal of Chinese Integrative Medicine

基　　金：上海市卫生局中医药科研基金资助项目(No.2006J009A)

摘　　要：通过频次法和分层聚类法探求《伤寒论》中甘草的量效规律。《伤寒论》中甘草的用量主要有4个层次:1两,主要与麻黄、杏仁、桂枝配伍,用于佐制麻黄发汗太过;2两,主要与桂枝、芍药,石膏、知母,附子、干姜等配伍,具有温阳益气和养阴之效,还可解附子之毒,防治热邪耗气;3两,主要与半夏、人参配伍组成小柴胡汤、泻心汤等,适用于中焦之呕吐病证;4两,主要与干姜配伍,补益兼以缓急,其证多有急、悸、利等症状。甘草在《伤寒论》中多用于虚、缓、寒证,以邪实为主者常用1、2两,以正虚为主者用3、4两。In order to explore the dose-response patterns of Gancao （Radix Glycyrrhizae） in Shanghan Lun （Treatise on Febrile Diseases）, all prescriptions containing Gancao in Shanghan Lun were analyzed by frequency and hierarchical clustering analysis. The doses of Gancao used in Shanghan Lun ranged from six zhu （Chinese unit, and one zhu is equal to 0.65 g） to four liang （Chinese unit, and one liang is equal to 15. 625 g）. Doses of one, two, three or four liang were commonly used. One liang Gancao as juvantia was usually matched with Mahuang （Herba Ephedrae）, Xingren （Semen Armeniacae） and Guizhi （Ramulus Cinnamomi） for restricting the excessive diaphoresis of Mahuang. Two liang Gancao was often matched with some couple drugs, such as Guizhi and Shaoyao （Radix Paeoniae）, Shigao （Gypsum Fibrosum ） and Zhimu （ Rhizoma Anemarrhenae）, Fuzi （Radix Aconiti Lateralis） and Ganjiang （ Rhizoma Zingiberis）, for warming yang to supplement qi, nourishing yin, detoxifying FuzJ, and preventing qi impairment from heat evil. Three liang Gancao was mainly matched with Banxia （Rhizoma Pinelliae） or Renshen （Radix Ginseng） for treating middle energizer emesis. Four liang Gancao was matched with Ganjiang or tonifying herbs for invigorating vital qi and relieving spasm in deficiency syndromes with contraction, palpitation or diarrhea, Gancao is used for treating many syndromes in Shanghan Lun. It is frequently used to treat excess or heat syndromes with one or two liang in a dose and deficiency or cold syndromes with three or four liang in a dose.

关 键 词：伤寒论 甘草 配伍 剂量效应关系 药物 

分 类 号：R222[医药卫生—中医基础理论]