邻苯二甲酸二(2-乙基己基)酯对大鼠不同脏器的损伤  

Organs Damage Caused by Di-(2-ethylhexyl) phthalate in Rats

作　　者：衷筱琴[1] 蔡红平[2] 万红萍[3] 肖雯[1] 

机构地区：[1]南昌大学基础医学院病理教研室,江西南昌330006 [2]南昌大学公共卫生学院环境卫生教研室,江西南昌330006 [3]南昌大学第一附属医院病理科,江西南昌330006

出　　处：《环境与健康杂志》2009年第3期212-214,F0003,共4页Journal of Environment and Health

基　　金：南昌大学科研课题(2008J03)

摘　　要：目的探讨邻苯二甲酸二(2-乙基己基)酯(DEHP)对大鼠各组织器官造成的损伤。方法选用雄性Wistar大鼠50只,随机分为5组,每组10只,以灌胃方式染毒DEHP,4个染毒组剂量分别为1500、3000、4500、6000mg/kg,阴性对照组每天灌胃相同体积的食用油,各组每4d称重1次,28d后称重处死,计算脏器系数,并做病理学检查。结果4个染毒组随DEHP浓度的升高,其体重均数有依次降低的趋势,各染毒组大鼠体重均数普遍低于溶剂对照组(P<0.05,P<0.01),4500和6000mg/kg组大鼠染毒24d后,出现了体重停止增长且有体重减轻的现象;大鼠肝脏、肾脏、心脏的脏器系数均高于对照组(P<0.05,P<0.01),而睾丸脏器系数则均低于对照组(P<0.05,P<0.01);同时大鼠肝脏、肾脏、心脏、睾丸在镜下观察均有不程度的损伤,并随着DEHP浓度的逐渐增高,各脏器损伤的程度也随之加重。结论DEHP对大鼠的脏器可造成一定程度的损伤,并随染毒剂量的增加有加重的趋势。Objective To study the effects of di-（2-ethylhexyl） phthalate （DEHP） on the organs of rats. Methods Male Wister rats were divided into five groups, four exposure groups and one control group, 10 in each. The exposure groups were given with DEHP at the doses of 1 500 mg/kg, 3 000 mg/kg, 4 500 mg/kg, 6 000 mg/kg respectively, by gavage, 28 consecutive days. The rats were weighed every 4 days, after 28 days, the rats were killed and the organ coefficients were calculated and the pathological examination was done . Results The weight of four exposure groups reduced significantly （P〈0.05, P〈0.01 ）compared with the control group, there was a cease and weight lose in the 4 500 mg/kg and 6 000 mg/kg dosage groups after exposure for 24 days. The coefficient of liver/body, kidney/body and heart/body significantly increased compared with the control group （P〈0.05, P〈 0.01 ）. The coefficient of testicle/body reduced compared with the control group （P〈0.05, P〈0.01 ）.At the same time, the organs were damaged in degrees in the pathological examination. The damage was more serious with the increased doses of DEHP . Conclnsion DEHP exposure may damage the organs in degrees with a close dependent manner in the rats.

关 键 词：邻苯二甲酸二(2-乙基己基)酯 大鼠 脏器系数 病理学 

分 类 号：R994.6[医药卫生—毒理学]