光聚合一步可控合成表面氨化的核壳型超顺磁性纳米凝胶及其表征  

Controllable synthesis and characterization of amino-functionalized magnetic nanogels via photopolymerization

作　　者：公彦宝[1] 王成运[1] 刘顺英[1] 罗淑芳[1] 黄进[1] 余家会[1] 刘士远[2] 

机构地区：[1]华东师范大学新药创制先进技术研究院,上海200062 [2]第二军医大学附属长征医院医学影像科,上海200003

出　　处：《核技术》2008年第10期751-755,共5页Nuclear Techniques

基　　金：国家自然科学基金(20504010);973计划(2009CB930000);上海市自然科学基金(07ZR14034);上海市纳米专项(0652nm009，0752nm022)资助

摘　　要：用部分还原共沉淀结合离心分离合成超顺磁性Fe_3O_4纳米粒子,以其为核,N-(2-氨乙基)甲基丙烯酰胺盐酸盐N-(2-Aminoethyl)methacrylamide,AEM·HCI)为单体,N,N'-亚甲基双丙烯酰胺(MSA)为交联剂,采用光聚合原位一步合成粒径可控的表面氨化的超顺磁性核壳型Fe_3O_4纳米凝胶。探索了单体、交联剂量及光照时间对纳米凝胶粒径的影响,并用动态光散射仪(DLS)、TEM、FTIR、TGA、UV、多功能磁测量仪等表征了纳米凝胶的粒径、粒径分布、形貌、结构、磁响应性及稳定性。结果表明:改变单体、交联剂量及光照时间可得到不同粒径、粒径分布均匀的超顺磁性纳米凝胶;与Fe_3O_4纳米粒子相比,纳米凝胶的磁饱和强度略有降低,但其高的Zeta电位使其稳定性大大提高。Core-shell Fe3O4 nanogels with controllable sizes were synthesized under UV irradiation using Fe3O4 nanoparticles as core, N-（2-Aminoethyl）methacrylamide （AEM） as monomer and MBA as cross-linker. The effects of AEM and MBA concentrations and irradiation time on particle sizes of Fe3O4 nanogels were investigated. The particle size, size distribution, morphology, structure and magnetism of the nanogels were characterized by dynamic light scattering, transmission electron microscopy, FTIR, therrnogravimmetric analysis, and vibrating sample magnetometer. The results showed that superparamagnetic nanogels with different sizes and narrow size distributions could be synthesized by controlling the irradiation time and concentrations of monomer and cross-linker. Comparing with Fe3O4 nanoparticles, the stability of magnetic nanogels was improved dueto their high zeta potential, although their saturation magnetization showed a little tendency to decrease.

关 键 词：光聚合 原位可控合成 表面氨化 超顺磁性 核壳型纳米凝胶 

分 类 号：O635[理学—高分子化学]