海洛因依赖和戒断大鼠血液及下丘脑中β-EP含量变化研究  

Study on β-EP content change of blood and hypothalamus in heroin dependence and withdrawal rats

作　　者：秦伟[1] 秦继迅[2] 余德芊[1] 潘贵书[1] 

机构地区：[1]遵义医学院生理学教研室,贵州遵义563003 [2]遵义医学院生物学教研室,贵州遵义563003

出　　处：《遵义医学院学报》2008年第6期568-570,共3页Journal of Zunyi Medical University

基　　金：遵义医学院中青年基金编号:院发(2006)006

摘　　要：目的了解海洛因依赖和戒断大鼠β-内啡肽(β-endorphin,β-EP)含量变化,初步探讨海洛因成瘾的神经生物学机制。方法按剂量递增原则,给SD大鼠皮下注射海洛因建立海洛因成瘾大鼠模型,确定成瘾后放射免疫法测定依赖和戒断大鼠血浆、下丘脑内β-EP含量。结果海洛因依赖大鼠血液和下丘脑β-EP含量显著低于对照组(P<0.05);海洛因戒断大鼠血液和下丘脑β-EP含量较依赖组升高(P<0.05),与对照组比较无差异(P>0.05)。结论海洛因依赖和戒断时大鼠血液及下丘脑β-EP含量发生了改变。Objective To observate β-endorphin （β-EP） content in heroin dependence and withdrawal rats,and discuss the neurobiology mechanism prehminarily of heroin-addiction.Methods Heroin was injected according to the princicle of daily increasing dose to establish heroin-addiction models of rats, after heroin-addiction model was established, determinating β- EP content of plasma and hypothalamus in heroin dependence and withdrawal rats by RIA （radioimmunoassay）.Results β-EP content of blood and hypothalarhus in heroin addiction rat was significantly lower than control group （P〈0.05）;β-EP content of blood and hypothalamus in heroin withdrawal rat was higher than dependence group（P〈0.05）,it was no significant difference compared with the control group （P〉0.05）.Conclusions β-EP content of blood and hypothalamus has changed in heroin dependence and withdrawal rats.

关 键 词：海洛因 依赖 戒断 Β-EP 

分 类 号：R338[医药卫生—人体生理学]