通脉大生片对肾虚排卵障碍不孕大鼠下丘脑-垂体-卵巢轴的影响  

Mechanism of Tong-mai-da-sheng Tablet Action in deficient kidney Ovulation obstacle Sterility

作　　者：宋帮丽[1] 傅春华[1] 黄金珠[1] 方云芸[1] 马洁[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《成都中医药大学学报》2009年第1期43-45,50,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：四川省中医药管理局课题(No.200617310-299)

摘　　要：目的:探讨通脉大生片对肾虚型排卵障碍不孕症的治疗作用机制。方法:建立雄激素致无排卵大鼠模型。分通脉大生片组高剂量组、通脉大生片组低剂量组、模型组、空白组。观察体重,子宫和卵巢指数,子宫和卵巢病理形态学,血清FSH、LH、E2水平。结果:通脉大生片组与模型组比较,通脉大生片能够增加ASR大鼠子宫指数和卵巢指数(P<0.05)。子宫、卵巢组织形态学表明,通大生片组大鼠子宫内膜比模型组增厚,腺体数目增多。卵巢内有生长卵泡和成熟卵泡,数量明显增多。通脉大生片能够升高大鼠E2、FSH、LH水平(P<0.05)。结论:通脉大生片有促进卵泡发育成熟的作用,能够提高E2、FSH、LH水平,该作用可能通过调节下丘脑-垂体-卵巢轴来实现的。Objective： To explore mechanism of Tong-Mai-Da-Sheng Tablet （TMDST） ＇s of action in deficient kidney Ovulation obstacle Sterility. Methods： Replicate deficient kidney Ovulation obstacle female rat model, then rando reLy dividing them info three groups： high dosage of TMDST group, low dosage of TMDST group, yougui pill （YGP）, model group, setting up blank group in addi- tion. Observing and stating the content of weight, sex circle, uterus index, ovarian index, ovarian fonicle, endormetfium. Determining the content of serum estradiol （ E2 ）, stimulating regular sex circles were found in TMDST group. After TMDST treatment the uterus index and ovarian index increased significantly （ P 〈 0. 05 ） . The endormetrium were thicker and growing follicle in ovary were improved obviously in TMDST group. Compared with model group, the serum estmdiol （E2 ）, stimulating hormone （FSH） and luteinizing hormone （LH） were increased. （P 〈 0.05 ） in TMDST group. Condusion： TongMaiDaSheng tablet can promote the foLLicle growth, can increase the serum estradiol （ E2 ） , stimulating hormone （FSH） and luteinizing hormone （LH） . The effect may be achieved through the multiple actions of hypothalamus- pituitary- ovary.

关 键 词：通脉大生片 肾虚 排卵障碍 实验研究 

分 类 号：R271.14[医药卫生—中医妇科学] R285.5[医药卫生—中医学]