DNA甲基化与乳腺癌的关系研究进展  

Progress on Relationship between DNA Methylation and Breast Cancer

作　　者：刘莎[1] 向佳梅[1] 王立明[1] 

机构地区：[1]重庆市第三军医大学新桥医院普外科,重庆400037

出　　处：《现代生物医学进展》2009年第5期960-963,共4页Progress in Modern Biomedicine

摘　　要：表观遗传学分子机制,其中包括DNA甲基化,通过细胞分裂逐代遗传,在基因转录调控中发挥着重要作用。尽管DNA甲基化是正常哺乳动物胚胎形成所必需的,但在致癌作用中却经常观察到DNA的低-和高-甲基化现象。DNA甲基化在癌症的发生和发展中起着重要作用,它使得许多抑癌基因转录沉默,最终导致癌基因的无限增殖化。许多肿瘤抑制基因启动子区异常甲基化与乳腺癌的形成密切相关,比如ER,pl6,APC,RASSF1A,BRCA1等。DNA甲基化是可逆的过程,通过DNA去甲基化制剂,可以使基因恢复正常表达功能。因此,DNA去甲基化制剂在乳腺癌的治疗中具有重要临床意义。Epigenetic abnormalities, such as aberrant methylation of DNA, are inherited over cell divisions, and play important roles in gene regulation and expression. Although DNA methylation is necessary for normal mammalian embryogenesis, both hypo- and hyper-methylation of DNA are frequently observed in carcinogenesis and other pathological disorders. Aberrant DNA methylation plays important role in the course of carcinogenesis and development in breast cancer. DNA hypemlethylation silences the transcription of many tumor suppressor genes, resulting in immortalization of tumor cells. Promoter region hyper-methylation of several tumor suppressor genes plays crucial roles in carcinogenesis of breast cancer, including ER, p16, APC, RASSF1A, BRCA1, and so on. The reverse process, demethylation and restoration of normal functional expression of genes, is augmented by DNA methylation inhibitors. So DNA demethy- lated agents may be useful in treatment of breast cancer.

关 键 词：乳腺肿瘤 基因 肿瘤抑制 DNA甲基化 

分 类 号：R543[医药卫生—心血管疾病]