抵抗素、Ⅱ型糖尿病和血管形成  

Resistin, Type II Diabetes, and Angiogensis

作　　者：王方圆[1] 吴明媛[1] 谢超[2] 韩伟[1] 

机构地区：[1]上海交通大学药学院再生医药学研究室,上海200240 [2]上海交通大学农业与生物学院上海市兽医生物技术重点实验室,上海200240

出　　处：《现代生物医学进展》2009年第5期967-969,共3页Progress in Modern Biomedicine

摘　　要：抵抗素是近年来新发现的一个富含半胱氨酸的多肽,由于具有拮抗胰岛素的作用而得名。在啮齿类动物中,抵抗素主要由脂肪细胞特异性表达和分泌。目前对抵抗素的研究已获得了重要突破与进展,其三维结构也得到了证实。它不仅是联系肥胖症和Ⅱ型糖尿病的重要蛋白,而且具有多种生物学功能,如干扰肝细胞的糖原代谢、促进内皮细胞增殖迁移和血管生长、减少心梗面积等。本文主要介绍抵抗素的最新研究进展,以及抵抗素在Ⅱ型糖尿病和血管形成中的重要作用。Resistin, a cysteine-rich polypeptide, is a recently discovered adipocytokine and named for its role of insulin resistant. Resistin is mainly expressed in adipocyte of rodent. Three dimensional structure of Resistin has been resolved. Resistin represents an important molecular linker between type Ⅱ diabetes and obesity through affecting liver glycogen metabolism. It also induces angiogenesis through regulation of microvascular endothelial cells and smooth muscle cells. Furthermore, Resistin reduces the size of myocardial infarction in animal models. This review will summarize the current progress of Resistin and its roles in type Ⅱ diabetes and angiogenesis.

关 键 词：抵抗素 胰岛素抵抗 糖原代谢 血管生成 心脏保护 

分 类 号：R318.15[医药卫生—生物医学工程]