蛋白质组学在肝癌相关生物分子研究中的应用进展  

Searching Biomolecules Related to Liver Cancer by Proteomics

作　　者：杨德会[1] 刘潇聪[2] 

机构地区：[1]成都军区总医院胃肠科,四川成都610083 [2]成都军区总医院传染科,四川成都610083

出　　处：《现代生物医学进展》2009年第5期973-975,共3页Progress in Modern Biomedicine

摘　　要：蛋白质组学以细胞、组织或器官表达的所有蛋白质为研究对象,通过双向凝胶电泳、生物质谱技术及生物信息学等方法,达到分离、鉴定、分析蛋白质的目的。肝癌发病过程涉及多基因的改变,必然伴随蛋白质表达的改变。以蛋白质组学的方法,通过比较正常肝组织与肝癌组织表达的蛋白质,寻找与肝癌发生、发展、转移及检测、治疗有关的生物分子。Proteomics studies all the proteins that expressed in cells, tissues or organs. By means of 2D-PAGE, MS and bioinformatics, we could separate, identify and analyze proteins, particularly their structures and functions. Hepatocarcinogenesis is a slow multistep and multifactorial process, usually a consequence of long-term inflammation and fibrosis, which involves the progressive accumula- tion of changes at the level of gene and protein expression. Thereby, we can detect the proteins differently expressed in tissues of liver cancer and normal liver by proteomics, analyze whether it relates to the genesis, progression or metastasis of liver cancer, and find out new biomolecules which could be used as diagnostic markers or therapeutic targets for liver cancer.

关 键 词：肝癌 蛋白质组 生物分子 

分 类 号：R331[医药卫生—人体生理学] R735.7[医药卫生—基础医学]