顶空气相色谱法测定脉络通颗粒中大孔吸附树脂有机残留物  

Headspace GC determination of macroporous resin residual organic substances in Mailuotong granules

作　　者：赵沈娟[1] 石晶萍[1] 祖若玉[1] 李明[1] 李雪兰[1] 黄新兰[1] 

机构地区：[1]扬子江药业集团质量管理部,江苏泰州225321

出　　处：《药物分析杂志》2009年第3期458-461,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立脉络通颗粒中大孔吸附树脂有机残留物正己烷、苯、甲苯、二甲苯、苯乙烯、二乙基苯的测定法。方法:采用顶空气相色谱法测定大孔吸附树脂残留量,使用HP-INNOWax固定相的弹性石英毛细管柱;以高纯氮气为载气;以FID为检测器。结果:该法有良好的线性,r在0.9928～0.9993之间;精密度、重现性RSD均小于5%,平均回收率在74.2%～114.0%之间。结论:本法简便,快速,准确,可用于本品中正己烷、苯、甲苯、二甲苯、苯乙烯、二乙基苯残留量的测定。Objective：To establish a method for analysis of macroporous resin residual organic substances（n-hexane,benzene,toluene,xylene,styrene,diethylbenzene）in Mailuotong granules by headspace GC.Methods：The contents of macroporous resin residual organic substances were determined by headspace GC on HP-INNOWax column,with FID detector,high purity nitrogen as the carry gases.Results：There was a good linearity（r：0.9928-0.9993）.The RSD of precision and accuracy was less than 5%,the average recovery rate was in the range of 74.2%-114.0%.Conclusion：The method is simple,quick and accurate and can be used for quality control of Mailuotong granules

关 键 词：脉络通颗粒 大孔吸附树脂 顶空气相色谱法 有机残留物 

分 类 号：R917[医药卫生—药物分析学]