肌肉介导心钠素基因对 L-NNA 高血压大鼠的作用  

Effect of Intramuscular Transfer of Atrial Natriuretic Factor Eukaryotic Expression Vector on L NNA Hypertensive Rats

作　　者：秦阳君[1,2] 张晨晖[1,2] 张继峰 丁金凤[1,2] 陈光慧 汤健 

机构地区：[1]北京医科大学心血基础研究所 [2]阜外医院心血管研究所

出　　处：《高技术通讯》1998年第2期45-47,共3页Chinese High Technology Letters

基　　金：863计划资助项目

摘　　要：用重组人心钠素基因真核表达质粒ｐｃＤＮＡ３／ＡＮＦ，通过基因缝线转移至Ｌ－ＮＮＡ高血压大鼠股四头肌，发现可明显降低Ｌ－ＮＮＡ引起的高血压，并产生明显的利钠利尿作用。提示肌肉介导心钠素基因，作为一种ＤＮＡ药物治疗高血压，可能具有潜在应用价值。With the method of gene suture, the ANF cDNA eukaryotic expessing plasmid was transferred into the quadricep of L NNA hypertensive rats. It was found that the blood pressure was significantly decreased, and the ruinary volume and sodium excretion were obviously increased after gene transfer. The results suggest that muscle mediated ANF gene transfer has the potential application in hypertension therapy.

关 键 词：肌肉介导 基因 心钠素 高血压 

分 类 号：R972.4[医药卫生—药品]