针灸治疗痤疮临床随机对照试验疗效及安全性评价  

Evaluation of therapeutic effect and safety for clinical randomized and controlled trials of treatment of acne with acupuncture and moxibustion

作　　者：黎波[1] 柴华[1] 杜元灏[2] 肖丽[1] 熊俊[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193

出　　处：《中国针灸》2009年第3期247-251,共5页Chinese Acupuncture & Moxibustion

基　　金：国家“十一五”科技支撑计划项目:2006BAI12B01

摘　　要：目的:评价针灸治疗痤疮的临床疗效及安全性,分析目前临床研究的现状。方法:检索PubMed、Cochrane图书馆、CBM数据库、CNKI数据库等收集针灸治疗痤疮的临床随机对照试验,选择符合纳入标准的临床试验,以Cochrane系统评价手册5.0进行质量评价,统计学分析采用RevMan4.2.8。结果:17篇文献符合纳入标准,共1613例患者。17项研究采用治愈率为评价指标,Meta分析显示针灸治疗痤疮对照常规西药,组间比较差异有统计学意义[合并RR(随机效应模型)=2.96,95%CI(1.63,4.91),Z=4.08,P<0.0001];针灸综合疗法对照针灸单一疗法,组间比较差异有统计学意义[合并RR(固定效应模型)=2.51,95%CI(1.76,3.57),Z=5.11,P<0.00001]。结论:针灸治疗痤疮安全、有效,对照常规西药可能有一定优势,针灸综合疗法优于单一疗法,但因纳入部分文献质量较低,结论尚不确定;今后应对其不同分级和证型进行高质量研究,进一步验证针灸治疗痤疮的优势性,对针灸不同疗法应进行对比研究,以提高疗效。Objective To evaluate the therapeutic effect and safety of acupuncture and moxibustion for treatment of acne, and to analyze the current situation of clinical studies at present. Methods Retrieve PubMed, Cochrane library, CBM databank, CNKI databank, etc., and collect the randomized and controlled trials of treatment of acne with acupuncture and moxibustion, and select clinical trials conforming with the enrolled criteria, and conduct evaluation of quality with Cochrane systematic manual 5.0 , and RevMan 4.2.8 was used for statistical analysis. ResultsSeventeen papers, including 1613 cases, conformed with the enrolled criteria. Seventeen studies adopted the cured rate as the evaluation index, Meta-analysis showed treatment of acne by acupuncture and moxibustion with routine western medicine as control, significant difference for inter-group comparison [combined RR （random efficacy model）=2.96, 95%CI （1.63,4.91）, Z=4.08. P〈0.0001]; comprehensive acupuncture and moxibustion therapy was controlled with single acupuncture-moxibustion therapy, significant difference for inter-group comparison [combined RR （fixed efficacy model）=2.51, 95%CI （1.76, 3.57）, Z=5.11, P〈0.00001]. Conclusion Acupuncture-moxibustion is safe and effective for treatment of acne, and it is possibly better than routine western medicine, and the comprehensive acupuncture-moxibustion therapy is better than single acupuncture-moxibustion therapy. The conclusion has not been determined yet, because lower quality of a part of literature enrolled.

关 键 词：随机对照试验 痤疮 文献计量学 综合分析 安全管理 

分 类 号：R246.7[医药卫生—针灸推拿学]