糖尿病角膜创伤愈合过程中信号通路的研究进展  

Research progress in signal pathway of corneal wound healing in diabetes mellitus patients

作　　者：张颖[1] 吴欣怡[1] 

机构地区：[1]山东大学齐鲁医院眼科,山东济南250012

出　　处：《基础医学与临床》2009年第3期326-329,共4页Basic and Clinical Medicine

基　　金：山东省科技厅科技攻关项目(2007GG2002031);教育部博士点基金(200704022081)

摘　　要：糖尿病患者角膜创伤愈合延迟可能与角膜细胞中MAPK信号通路活化、TGF-β信号通路传导减弱、胰岛素信号通路相关基因表达异常及胰岛素受体表达下降有关联。此外,NF-κb炎性通路以及细胞色素C凋亡通路异常激活,也对糖尿病角膜创伤愈合产生不利影响。本文旨在综述糖尿病角膜创伤愈合过程中相关信号通路的研究进展。Delayed wound healing of diabetic cornea may be associated with the activation of MAPK signal pathway, impaired signal transduction of TGF-β signal pathway, abnormal expression of genes related to insulin signal pathway and reduced expression of insulin receptor. In addition, the activation of NF-Kb and cytochrome C signal pathway also has harmful influence on delayed wound healing. This paper reviews research progress about signal pathway of delayed wound healing in diabetic cornea.

关 键 词：信号通路 角膜创伤愈合 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R779.1[医药卫生—内科学]