药用真菌脂溶性提取物对PC12细胞氧化应激损伤保护作用的研究  

Protective effects of lipophilic extracts of medicinal fungi against oxidative-stress damage in PC12 cells

作　　者：庞小博[1,2] 张劲松[2] 唐庆九[2] 郝瑞霞[2] 杨焱[2] 贾薇[2] 冯娜[2] 刘艳芳[2] 潘迎捷[3] 

机构地区：[1]南京农业大学生命科学学院微生物系,南京210095 [2]上海市农业科学院食用菌研究所,上海201106 [3]上海水产大学食品科学学院,上海200090

出　　处：《上海农业学报》2009年第1期9-13,共5页Acta Agriculturae Shanghai

基　　金：上海市科技兴农重点攻关项目[沪农科攻字(2002)第1-4-3号]资助

摘　　要：利用PC12细胞氧化应激损伤模型，对6种药用真菌的49个脂溶性提取物进行筛选，研究表明，灵芝等药用真菌均具有氧化应激保护作用，其中桑黄和北虫草活性显著。29个样品在5～150mg／L对PC12氧化应激损伤的保护作用呈剂量依赖性增长。药用真菌脂溶性提取物对PC12细胞氧化应激损伤保护作用与药用真菌的种类密切相关，并且药用真菌的不同菌株对PC12细胞氧化应激损伤保护作用也是不同的。The screening test for 49 lipophilic extracts of 6 medicinal fungi by using the oxidativestress damage model of PC12 cells showed that all the 6 medicinal fungi had a protective role against the oxidative-stress damage. The activities of Phellinus linteus and Cordyceps militaris were significant. The protective effects of the 29 samples between 5-150 mg/L against the oxidative-stress damage presented a dose-dependent growth. The protective effect of lipophilic extracts of medicinal fungi against the oxidative-stess damage in PC12 cells was closely related to the medicinal fungi＇s species, and different stains of the same medicinal fungus had a different protective effect against the oxida- tive-stress damage.

关 键 词：药用真菌 脂溶性提取物 氧化应激 PC12 保护作用 

分 类 号：S567.3[农业科学—中草药栽培]