兔肺白念珠菌病急性期CT表现分型的初步研究  

The initial study of typing on CT appearances in acute pulmonary candidiasis of rabbit

作　　者：谢丽璇[1] 刘士远[1] 陈友三[1] 刘锴[1] 薛峰[1] 张建[1] 

机构地区：[1]上海长征医院影像科,上海200003

出　　处：《医学影像学杂志》2009年第2期226-229,共4页Journal of Medical Imaging

摘　　要：目的:对兔肺白念珠菌病急性期的CT表现进行初步的分型。方法:24只新西兰大白兔随机分为实验组及对照组,实验组通过经皮气管穿刺法建立兔肺念珠菌病模型,对照组用同样方法注入生理盐水,于接种后隔日—次行CT扫描观察CT表现,并与病理对照。结果:成功建立13例兔肺念珠菌病模型,CT表现可分为小叶实变型6例,以胸膜下分布为主,病理表现为肺泡炎性渗出;叶段实变型3例,分布于肺低垂部,多表现为肺内出血性梗死灶;结节型2例,均多发,以分布支气管血管束周围多见,病理见肉芽肿性病变;磨玻璃型2例,双肺不对称分布,为肺泡及肺泡壁的炎细胞浸润。结论:原发性肺白念珠菌病急性期CT表现可分为四种类型,包括小叶实变型、叶段实变型、结节型和磨玻璃型。Objective： To investigate preliminary typing in CT appearances of pulmonary candidiasis. Methods： Twenty-four New Zealand rabbits, divided into experimental group and control group randomly. All the experimemal group rabbits were inoculated with the way of percutaneous trachea puncture, and the control group were injected with normal saline with the same way. Chest CT scan was per- formed every other day from the day performed incubation, the results was controlled with pathological changes. Results： 13 cases rabbit pulmonary candidiasis were performed successfully, the CT appearances can be devided into 4 types： included the type of sublobe consoliclarion （n = 6 ） Milch represent intra-alveolar exudate and often distribute under pleural membrane, lobe or section consolidation （n = 3 ） which represent hemorrhagic infarction and often distributed in the low department of lung, 2 cases belonged to the type of nodules which mainly found near bronchovascnlar bundle and represent granuloma, other 2 cases belonged to the type of ground-glass attenuation, which often asymmetrical distributed in bilateral lung and displayed interstitial proliferation or intra-alveolar exudates. Conclusion：Primarily pulmonary candidiasis can be devided into 4 types including the type of sublobe consolidation, lobe or section consolidation, nodules and ground-glass attenuation.

关 键 词：白念珠菌 肺念珠菌病 动物实验 体层摄影术 X线计算机 

分 类 号：R379.4[医药卫生—病原生物学] R814.42[医药卫生—基础医学]