电针诱发人脑活动的功能磁共振比较实验研究  

Experimental Study on fMRI in Human Brain with Electroacupuncture

作　　者：王伟[1] 徐海波[1] 孔祥泉[1] 黄劲柏[1] 支新[1] 刘玲[2] 王华[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院放射科,湖北武汉430022 [2]湖北中医学院

出　　处：《实用放射学杂志》2009年第3期305-308,共4页Journal of Practical Radiology

基　　金：基金项目：国家自然科学基金重大研究计划面上项目（编号：90209031）.

摘　　要：目的探讨电针特异性和穴位特异性脑活动。方法采用组块刺激模式,电针健康右利手志愿者的右侧合谷穴（9例）、阴陵泉（6例）和面部非穴位点（5例）,对全脑行平面回波血氧水平依赖功能磁共振成像（BOLD fMRI）扫描和高分辨率三维T1解剖像,用SPM2软件进行统计学预处理,然后将统计参数图叠加到三维解剖图像。结果电针可诱发多个脑区信号升高和降低;3组的共同激活区主要包括：双侧前额叶、双侧颞上回和双侧楔前叶;合谷组穴位特异性激活区包括：边缘系统、中线核群、扣带回嘴侧、对侧运动前回和双侧运动前区。结论电针灸脑反应可分为2部分：穴位特异性和电针特异性反应。Objective To explore the electroacupuncture-specific and point-specific activation of associated brain cortices induced by electroacupuncture. Methods 20 healthy subjects underwent BOLD fMRI during electroacupuncture stimulation at LI4 （Hegu） in 9 ones,SP9（yinlingquan） in 6 and non-meridian point in 5. A block-design paradigm was applied. The brain responses were analyzed using SPM tools. Results Signal increase and decrease were demonstrated in the multiple brain regions （P〈0. 001 ）. The common activated cortices included bilateral prefrontal cortex, bilateral superior temporal gyrus and bilateral precuneus. LI4- special activities were demonstrated at limbic system, midline nuclears group, rostral cingulate cortices, left precentralis gyrus and bilateral premotor cortices. Conclusion The specific activities of brain stimulated by electroacupuncture include point- specific and electroacupuncture- specific.

关 键 词：功能磁共振成像 针灸 脑 经络 

分 类 号：R445.2[医药卫生—影像医学与核医学] R245[医药卫生—诊断学]