妊娠肝内胆汁淤积症尿液总胆汁酸变化及意义  

Change and Significance of Urinary Total Bile Acids in Intrahepatic Cholestasis with Pregnancy

作　　者：徐洲[1] 邢爱耘[2] 万红芳[2] 王利民[2] 

机构地区：[1]四川省妇幼保健院妇产科,四川成都610031 [2]四川大学华西第二医院妇产科,四川成都610041

出　　处：《华西医学》2009年第2期317-319,共3页West China Medical Journal

摘　　要：目的:测定妊娠期肝内胆汁淤积症(ICP)患者血清及尿液的胆汁酸水平,探讨ICP时母体胆汁酸转运的变化及意义。方法:ICP患者(ICP组)及正常妊娠(对照组)各20例。血清及尿液总胆汁酸测定采用速率法。结果:(1)ICP组与对照组相比,血清及尿液中总胆汁酸水平均明显升高,差异有显著性(P<0.05);(2)对照组尿液总胆汁酸水平明显高于血清,差异有显著性(P<0.05),而ICP组血清和尿液总胆汁酸水平无显著性差异(P>0.05);(3)两组中血清与尿液总胆汁酸水平均无相关性(P>0.05)。结论:ICP患者母血中总胆汁酸水平明显增加,而总胆汁酸经尿液的排泄未成比例增加,这可加重胆汁淤积,引起围产儿不良结局。Objective：To detect the total bile acids（TBA）levels in maternal serum and urine of intrahepatic cholestasis of pregnaney（ICP）. To explore the change of bile acid tansporter and its significance in ICP. Methods：TBA levels in serum and urine were measured by velocimetry respectively in 20 gravidas complicated with ICP（ICP group）and 20 normal gravidas（control group）. Results：l, the serum and urinary TBA levels in ICP group were significantly higher than those in control group（P〈0.05）. 2, the urinary TBA levels were significantly higher than the serum TBA in control group（P d0.05）, However, there were no significant differences between the serum and urinary TBA levels in ICP group （P〉0.05）. 3,There were no significant correlation between the serum and urinary TBA levels in both groups（P〉0.05）. Conclusion：Correlating to great increase of serum TBA level there was no proportionally increased urinary secretion of TBA in ICP,which probably aggravates maternal cholestasis and is involved in the pathology of adverse fetal outcome.

关 键 词：总胆汁酸 妊娠期肝内胆汁淤积症 尿液 

分 类 号：R714.255[医药卫生—妇产科学]