氨苯砜脂质体凝胶的体外透皮吸收研究  

Cutaneous penetrance of dapsone liposomal gel in vitro

作　　者：王晓东[1] 闫军[1] 姜向海[1] 贾献慧[2] 唐文照[2] 

机构地区：[1]济南市皮肤病防治院,济南250001 [2]山东省医学科学院药物研究所,济南250062

出　　处：《中国麻风皮肤病杂志》2009年第3期177-179,共3页China Journal of Leprosy and Skin Diseases

基　　金：济南青年科技明星计划[2006]10109

摘　　要：目的:测定氨苯砜脂质体凝胶透皮吸收性。方法:采用Franz垂直扩散池,测量氨苯砜凝胶,2%、5%氨苯砜脂质体凝胶的透皮吸收量。结果:2%氨苯砜脂质体凝胶>5%氨苯砜普通凝胶>5%氨苯砜脂质体凝胶。结论:2%氨苯砜脂质体凝胶可以显著改善氨苯砜透皮吸收效果,为氨苯砜脂质体凝胶的制备提供了依据。Objective： To determine the cutaneous penetrance of dapsone liposomal gel in vitro. Methods： Franz diffusion cell method was used to measure the cutaneous permeation of dapsone gel, 2 % dapsone liposomal gel and 5% dapsone liposomal gel. Results： 2% dapsone liposomal gel had the best cutaneous permeation in vitro, followed by the general dapsone gel and 5% dapsone liposomal gel. Conclusion： 2% dapsone liposomal gel can improve the effect of cutaneous penetrance of dapsone, which provides a basis for the preparation of liposomes gel.

关 键 词：氨苯砜 脂质体 凝胶 透皮吸收 

分 类 号：R755[医药卫生—皮肤病学与性病学]