胰腺干细胞体外诱导分化研究进展  

Progress on the Induced Differentiation of Pancreatic Stem Cells in Vitro

作　　者：赵小丽[1] 兰海楠[1] 吴杭格[1] 王珊珊[1] 闫峰[1] 郑鑫[1] 

机构地区：[1]吉林农业大学动物科技学院,吉林长春130118

出　　处：《动物医学进展》2009年第3期99-103,共5页Progress In Veterinary Medicine

基　　金：吉林省教育厅"十一五"科学技术规划课题(2007-16);吉林省科技发展计划项目(20080562)

摘　　要：胰腺干细胞是一种多能干细胞,具有无限分裂和永久自我更新的能力,可在特定因素的影响或诱导下,分化成胰腺导管、胰岛、外分泌腺泡等特定胰腺组织类型,甚至肝细胞。由胰腺干细胞诱导分化的胰岛β细胞在治疗Ⅰ型糖尿病和纠正部分Ⅱ型糖尿病中具有重要意义。论文就胰腺干细胞的存在部位、诱导干细胞为胰岛β细胞的生物活性物质、诱导分化为胰腺β细胞的方法及调控胰腺干细胞分化的信号通路等方面做一综述。Pancreatic stem ceils, a multi-functional stem cells, has unlimited differentiation and permanent self-renewal capacities. Under the influence or induction of certain factors,it may differentiate into pancreatic ductal, pancreatic exocrine gland bubble, other specific types of pancreatic tissues, and even liver cells. The pancreatic stem cell has the extremely great significance in curing type Ⅰ diabetes and correcting type Ⅱ diabetes partly. This article mainly summarized the existing spot, bioactive substances, methods in inducing pancreatic β ceils, and the signaling pathway for pancreas differentiation control and so on.

关 键 词：胰腺干细胞 诱导分化 Β细胞 

分 类 号：Q254[生物学—细胞生物学]