糖代谢异常患者血浆醛固酮水平变化的临床意义  

The clinical observation on RAA in patients with abnormal glucose metabolism

作　　者：王霞娟[1] 卜瑞芳[1] 顾敏峰[1] 蒋艳敏[1] 沈泓[1] 许岚[1] 邓振霞[1] 吴小庆[1] 黄建荣[1] 

机构地区：[1]南京医科大学附属无锡市人民医院,无锡214023

出　　处：《临床合理用药杂志》2009年第4期19-20,共2页Chinese Journal of Clinical Rational Drug Use

基　　金：南京医科大学发展基金资助项目(NY04059)

摘　　要：目的观察高血糖、高血压患者中肾素-血管紧张素-醛固酮(renin-angiotensin-aldosterone,RAA)水平,探讨是否RAAS的激活是2者共同的发病机制。方法用放射免疫分析法测定106例正常人、112例单纯糖代谢异常患者、101例单纯原发性高血压患者及127例糖代谢异常合并原发性高血压患者的血浆RAA水平和活性。结果3组醛固酮水平均明显高于CON组,差异有统计学意义(P<0.01),I-IGM常组中血管紧张素Ⅱ水平明显高于其他各组,差异有统计学意义(P<0.01),各组间肾素活性差异无统计学意义。血浆醛固酮水平与空腹血糖、肾素、收缩压、血管紧张素Ⅱ高度相关。结论高血糖和原发性高血压同样存在RAAS的激活,组织水平干预醛固酮应该成为血糖代谢异常患者的一个治疗目标。Objective To observe the level of renin -angiotensin -aldosterone（RAA） and explore the relation between RAA and abnormal glucose metabolism. Methods The level of RAA in 106 healthy people, 112patients with abnormal glucose metabolism, 101 cases with EH and 127 cases with the two diseases. Results The level of RAA in normal groups was obviously higher than that of other groups（ P 〈 0, 01 ）, especially in the abnormal glucose metabolism group. There was no significant difference of PRA between these groups. Conclusion The actibation of RAA can appear in patients with EH and hyperglycemia. So it is necessary to control the level of RAA in clinical practice.

关 键 词：糖代谢异常 原发性高血压 血管紧张素Ⅱ 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]