姜黄素滴丸在大鼠体内药代动力学研究  

Pharmacokinetics of curcumin dropping pill in rats in vivo

作　　者：韩刚[1] 范颖[1] 翟冠钰[1] 董月[1] 原海忠[1] 林庆辉[1] 

机构地区：[1]华北煤炭医学院药学系唐山市新药基础研究重点实验室,河北唐山063000

出　　处：《中成药》2009年第3期377-379,共3页Chinese Traditional Patent Medicine

摘　　要：目的:以聚乙二醇6000(PEG)为基质制备姜黄素滴丸(固体分散体)和以淀粉为基质的姜黄素片相比较,研究基质对姜黄素在大鼠体内的药动学过程的影响。方法:SD大鼠分别灌胃,给予纯姜黄素、姜黄素片剂、姜黄素滴丸,HPLC法测定大鼠体内姜黄素的血药浓度,使用3P97软件计算药动学参数。结果:在大鼠体内药学过程符合单室模型,姜黄素滴丸与姜黄素相比Cmax、AUC显著增大,姜黄素滴丸对姜黄素的相对生物利用度为1 046%。结论:姜黄素滴丸能显著提高姜黄素在大鼠体内的生物利用度。AIM： To compare curcumin dropping pill prepared from polyethylene glycol 6000 with curcumin tablet prepared from starch to study the effect of matrix on the pharmacokinetics of curcumin and in rats.METHODS： The rats fed with pure curcumin, curcumin tablet and curcumin dropping pill. The curcumin concentration of in whole blood was determined by HPLC. The data processing was completed by the software 3P97. RESULTS： The concentration-time curve of curcumin and curcumin dropping pill were fit to an one-compartment model. The total areas of curcumin dropping pill under the plasma concentration-time curve AUC were larger than that of pure curcumin. The relative bioavailability of curcumin dropping pill was 1 046% CONCLUSION ： The curcumin dropping pill could increase bioavailability of curcumin in rats of curcumin tablet in vivo remarkably.

关 键 词：姜黄素 滴丸 固体分散体 药动学 生物利用度 大鼠 

分 类 号：R969.1[医药卫生—药理学]