早产儿尿S100B蛋白测定对早期SEH-IVH的临床评价  

Measurement of urinary S100B protein concentrations for the early evaluation of subependymal and intraventricular hemorrhage in preterm infants

作　　者：于文红[1] 刘瑞霞[1] 孙夫强[1] 刘群[1] 董凯军[2] 

机构地区：[1]天津医科大学第二医院新生儿科,天津300211 [2]天津医科大学第二医院免疫室,天津300211

出　　处：《天津医科大学学报》2009年第1期16-18,共3页Journal of Tianjin Medical University

基　　金：天津医科大学第二医院科研基金资助项目(Y200605)

摘　　要：目的:探讨动态监测早产儿尿S100B蛋白对室管膜下及脑室内出血(SEH-IVH)的临床意义。方法:对住院早产儿84例于生后24h及120h留尿测定尿S100B蛋白,同时观察临床表现及头颅B超检查,对早产儿SEH-IVH进行早期评估。结果:SEH-IVH组(27例)尿S100B蛋白水平均高于对照组(44例),两组比较存在统计学差异(均P<0.05)。SEH-IVHⅠ级16例,SEH-IVHⅡ级8例,SEH-IVHⅢ级3例,尿S100B蛋白随SEH-IVH分级增加,差异存在统计学意义(均P<0.05)。SEH-IVH27例中13例在生后24h时尿S100B蛋白即升高,10例为生后120h检测时升高,4例变化趋势平稳;对照组44例S100B蛋白动态检测呈下降趋势。84例早产儿其中痊愈54例,好转27例,恶化及死亡3例,病情恶化及死亡者尿S100B蛋白水平最高,24h可高达(8.32±1.90)μg/L。结论:动态监测尿S100B蛋白水平结合临床表现及影像学检查对早产儿SEH-IVH可早期做出更客观的评价,有助于判断预后。Objective： To investigate the clinical value of measurement of urinary S100B protein concentrations in preterm infants with SEH-IVH. Methods： The urinary S100B protein concentrations were measured in 84 preterm infants using ELISA at 2 predetermined time points （24 hours and 120 hours after birth ）.At the same time ,routine clinical observations, neurologic patterns, ultrasound screens were recorded. Results： S100B protein concentrations were significantly higher in samples collected at 2 monitoring time points from preterm infants with SEH- IVH （n=27） than in samples from those without SEH- IVH （P〈0.05） ;The S100B protein concentrations were different among SEH-IVH Ⅰ, SEH-IVH Ⅱ and SEH-IVH Ⅲ （P〈0.05）, and they were also different among preterm infants with different prognosis. In infants those died or deteriorated, the S100B levels in urine were significantly higher than those of others （P〈0.05）.Conclusion： Longitudinal S100B protein measurements in urine combined with clinical presentation and ultrasound screen are helpful to identify preterm infants with SEH-IVH and are beneficial to predict prognosis.

关 键 词：婴儿  早产 S100B 出血  颅内 

分 类 号：R722.6[医药卫生—儿科]