聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效观察  

Clinical effect of Pegylated interferon α-2a on treating chronic hepatitis C

作　　者：李红梅[1] 蒋孝华[1] 刘书香[1] 邱红梅[1] 邓绪乐[1] 

机构地区：[1]南华大学附属第一医院肝病研究中心

出　　处：《中国感染控制杂志》2009年第2期107-109,共3页Chinese Journal of Infection Control

摘　　要：目的研究聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效。方法设观察组（接受聚乙二醇干扰素α-2a治疗，联合利巴韦林口服）36例，对照组（接受普通干扰素α-2a治疗，联合利巴韦林口服）32例，在治疗前、治疗中、48周治疗结束及随访24周后，分别检测丙型肝炎病毒（HCV）RNA、血清丙氨酸转氨酶（ALT），比较两组治疗效果。结果48周治疗结束时，观察组的病毒学应答率和生物化学应答率均为88．89％，对照组分别为75．00％、81．25％，两组治疗结束时疗效无明显差异（均P〉0．05）。观察组早期病毒学应答率、持续应答率分别为47．22％、81）．55％，明显高于对照组的12．50％、31．25％（分别Χ^2=9．57，P〈0．05；Χ^2=16．84，P〈0．05）；观察组复发率为8．33％，显著低于对照组的43．75％（Χ^2=11．33，P〈0．05）。结论聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效优于普通干扰素α-2a。Objective To evaluate the effect of Pegylated interferon （PEG-IFN）α-2a on treating chronic hepatitis C. Methods Sixty-eight chronic hepatitis C cases were divided into observation and control group, 36 cases in observation group received PEG-IFN α-2a plus ribavirin, 32 cases in control group received interferon plus ribavirin, HCV RNA and serum alanine transaminase （ALT） were detected in two groups before treatment, during treatment, at the end of 48-week treatment and 24-week of follow-up, the treatment effect was compared between two groups. Results At the end of 48-week treatment, virological response rate and biochemical response rate were both 88. 89%in observation group, and it was 75.00% and 81.25% respectively in control group, there were no significant difference in the treatment effect at the end of treatment between two groups（ both P〉 0. 05）. The early virological response rate and sustained virological response rate was 47. 22% and 80. 55 % respectively in observation group, which was significantly higher than 12. 50% and 31.25% respectively in control group （Χ^2 = 9. 57, P〈 0. 05;Χ^2 = 16. 84, P〈0. 05; respectively） ; The relapse rate was 8.33% in observation group, which was significantly lower than 43. 75 % in control group （Χ^2 = 11.33, P〈0. 05）. Conclusion The effect of PEG-IFN α-2a on treating chronic hepatitis C is superior to IFN α-2a.

关 键 词：肝炎 丙型 慢性 肝炎病毒 丙型 干扰素Α-2A 聚乙二醇干扰素Α-2A 治疗结果 

分 类 号：R512.63[医药卫生—内科学]