增效抗凝血灭鼠剂对大鼠、小鼠CT和PT的影响及中毒鼠肝脏病理学观察  

Comparison of synegistic rodenticide effect on CT and PT in rats and mice and pathological observation in liver

作　　者：张国萍[1] 吴丁兰[1] 冯志勇[2] 常弘[1] 肖白玉[1] 姚丹丹[2] 郑志伟[1] 

机构地区：[1]中山大学生命科学学院,广东广州510275 [2]广东省农科院植物保护研究所,广东广州510640

出　　处：《广东农业科学》2009年第3期146-148,共3页Guangdong Agricultural Sciences

基　　金：广东省教育部产学研综合项目(2007B090400103)

摘　　要：以SD大鼠和小鼠为实验动物,检测和比较了增效抗凝血灭鼠剂对凝血时间(CT)和凝血酶原时间(PT)的影响,并观察增效抗凝血灭鼠剂中毒鼠的肝脏组织病理变化。结果表明,增效杀鼠醚能引起SD大鼠和小鼠的CT和PT显著延长,相对于杀鼠醚,相同浓度的增效杀鼠醚具有更强的抗凝血功能;中毒鼠肝脏病理学观察结果发现,增效灭鼠剂引起更严重的肝组织损伤、坏死,进一步阻碍其凝血功能,其中增效杀鼠醚对SD大鼠的影响程度大于小鼠,说明增效杀鼠醚对SD大鼠作用效果更明显。The present studies investigated synergistic rodentieide effect on SD rats and mice, and compared different effcts on coagulation time（CT） and prothrombin time（PT） in SD rats and mice and pathologicaltissues in liver. The results showed that synegistic rodenticide induced a prolonged CT and PT in SD rats and mice respectively, and there were significantly prolonged CT and PT compared with warfarin alone, which suggested synegistic rodenticide had more powerful anticoagulant effect than traditional warfarin. Pathological observation indicated that synegistic rodenticide induced more necrotic liver in toxic rats and mice. All results showed that synegistic rodenticide had a more significant effect on SD rats.

关 键 词：增效抗凝血灭鼠剂 大鼠 小鼠 凝血时间(CT) 凝血酶原时间(PT) 病理组织 

分 类 号：S482.55[农业科学—农药学]