糖尿病患者氧化还原水平变化的研究  

The Change of Redox Level in Type 2 Diabetes Mellitus

作　　者：谢飞舟[1] 邱悦群[1] 刘小勇[1] 胡艳[1] 陈杰斌[1] 

机构地区：[1]赣南医学院第三附属医院,江西赣州341000

出　　处：《赣南医学院学报》2009年第1期23-25,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨机体的氧化还原水平在2型糖尿病(2-DM)发生发展过程中的作用。方法:本实验设置葡萄糖调节受损组(D I组)、糖尿病组(DM组)、糖尿病并发症组(DC组)及两组健康对照组[年青对照组(HY组)和中老年对照组(HM组)],每组选择30例研究对象,测定空腹血清SOD、VC、VE及MDA、H2O2。结果:血清MDA、H2O2在年青对照组、中老年对照组、葡萄糖调节受损组、糖尿病组、糖尿病并发症组依次升高,糖尿病并发症组及糖尿病组的血清SOD、VC、VE显著低于对照组。结论:年青对照组比中老年对照组抗氧化应激能力较强;随着糖尿病病程进展,患者氧化应激水平增高,还原水平下降,提示机体氧化还原状态在糖尿病的病理改变中起重要作用。Objective：To investigate the role of the redox level in the progress of type 2 diabetes mellitus. Method： 30 young healthy persons （ HY group）, 30 middle - aged healthy persons （ HM group） , 30 glucose - adjusted injured patients （ DI group）, 30 type 2 diabetic mellitus （DM group） and 30 diabetic complication patients （DC group） were selected. Levels of SOD,VC,VE, MDA and H202 in fasting serum were measured. Result： The levels of MDA and H202 increased as following： HY group 〈 HM group 〈 DI group 〈DM group 〈 DC group. The serum SOD,VC and VE in DC group and DM group were obviously lower than that in HY group and HM group. Conclusion： The anti - oxidative ability in HY group was stronger than that in HM group. The oxidative level in- creased and reductive level decreased along with the progress of the diabetes mellitus. Tiffs suggests that redox level in body plays an important role in the pathological progress of type 2 diabetes mellitus.

关 键 词：氧化还原 2型糖尿病 自由基 

分 类 号：R587.1[医药卫生—内分泌]