轻亮胶囊的抗辐射作用研究  

Study of Antiradiation Effect of Qingliang Capsule

作　　者：林飞[1] 梁怿[1] 周立娜[1] 

机构地区：[1]中国药品生物制品检定所,北京100050

出　　处：《预防医学论坛》2009年第3期238-240,共3页Preventive Medicine Tribune

摘　　要：[目的]探讨轻亮胶囊对小鼠的抗辐射保护作用。[方法]用KM种小鼠连续14d给予0．35、0．70和1．40g／kg（分别相当于推荐人用量的5倍、10倍和20倍）轻亮胶囊灌胃，经3Gy^60Co—r射线辐照后，继续给予受试物至17-28d。检测小鼠的外周血及骨髓。[结果]受试物高剂量组能够明显对抗并减轻外周血白细胞数的减少（辐照3d升高57．1％；辐照14d升高61．1％）、骨髓有核细胞数的减少（抑制率由42．5％减少到22．8％）、微核细胞数的增多（抑制率为22．6％）和血清溶血素水平的降低（增加率31．6％）。[结论]轻亮胶囊具有抗辐射作用。[Objective]To explore the antiradiation effect of Qingliang capsule on rats. [Methods]0.35 g/kg,0.70 g/kg and 1.40 g/kg （5,10 and 20 times as human recommended dosage） of Qingliang capsule were continuously given to rats of KM species for 14 d. The rats were radiated with 3Gy ^60Co-r,then Qing-liang capsule was given to rats for 17 d or 28 d. [Results]The decrease of peripheral blood leucocytes（57. 1% increase after 3 days radiation and 61.1 % increase after 14 days radiation）,bone marrow karyota（ inhabitation rate decreased from 42.5 % to 22.8%）, the increase of micronucleus cell（ inhabitation rate was 22.6%） and the decrease of serum haemogglutinin（ increasing rate was 31.6 %） in high dosage group, was obviously inhibited and slowed. [Conclusion]Qing-liang capsule had antiradiation effect.

关 键 词：轻亮胶囊 小鼠 抗辐射 白细胞 骨髓细胞 微核 溶血素 

分 类 号：R14[医药卫生—公共卫生与预防医学]