经胃灌入高氧液对油酸型急性肺损伤家兔的治疗效果  

Therapeutic effect of hyperoxia solution on oleic acid-induced acute lung injury in rabbits

作　　者：徐瑞芬 冯旭阳[2] 刘蕊 张惠 徐礼鲜 王凤娟 

机构地区：[1]第四军医大学口腔医院麻醉科,西安市710032 [2]第四军医大学西京医院心脏内科 [3]第四军医大学口腔医院颌面外科,西安市710032

出　　处：《临床麻醉学杂志》2009年第2期144-146,共3页Journal of Clinical Anesthesiology

基　　金：国家科技部创新基金项目(00c26226110464)

摘　　要：目的研究经胃灌入高氧液(HO)对油酸型急性肺损伤(ALI)家兔的治疗作用。方法以复方氯化钠为基液制备HO。将18只家兔随机均分为油酸致伤组(A组)、HO治疗组(B组)和正常对照组(C组)。A、B组均经耳缘静脉注入油酸0.06ml/kg建立ALI模型,C组注入等量生理盐水。B组于注射油酸30min时经胃灌入HO20ml/kg,A、C组灌入等量复方氯化钠。各组分别在ALI模型制备前(0min)、注射油酸后30、60、120min经右颈外动脉抽血进行血气分析,并测定肺水含量、肺体比值及病理检查。结果与C组相比,A组PaO2、PaCO2明显降低(P<0.01),肺水含量、肺体比值及肺损伤评分明显增高(P<0.01),镜下见肺灶性出血,间质、肺泡水肿,大量炎性细胞浸润。B组经HO治疗后迅速提升PaO2、PaCO2(P<0.05),减轻肺水肿(P<0.01)。结论经胃灌入HO对油酸型ALI家兔有治疗作用。Objective To investigate the effect of hyperoxia solution （HO） taken orally on acute lung injury（ALI） induced by oleic acid in rabbits. Methods Eighteen rabbits were randomly divided into three groups with 6 rabbits each： oleic acid group （group A）, hyperoxia solution group （group 13） and control group（group C）. ALl model was established in group A and group B by injected oleic acid 0.06 mi/kg, while rabbits in group C were given salt liquid. HO 20 ml/kg was perfused via stomach in group 13 30 rain after the oleic acid infusion. The blood gas analysis and content of lung water were observed at different time points. Results Compared with those in group C, PaO2. PaCO2 decreased （P〈0.01）, content of lung water markedly increased in group A （P〈0.01）. After treatment with HO, PaO2 and PaCO2 significantly increased （P〈0.05）, content of lung water decreased （P〈0.01） in group B. Conclusion Hyperoxia solution has beneficial effect on ALI induced by oleic acid.

关 键 词：高氧液 急性肺损伤 血气分析 

分 类 号：R563.8[医药卫生—呼吸系统]