乳化异氟醚同咪唑安定的麻醉相互作用  

Anesthetic interaction of emulsified isoflurane with midazolam

作　　者：杨经文[1,2] 柴云飞[1] 甘净[1] 张文胜[1] 刘进[1] 

机构地区：[1]四川大学华西医院麻醉科,成都市610041 [2]湖北省十堰市郧阳医学院附属东风医院麻醉科

出　　处：《临床麻醉学杂志》2009年第2期157-159,共3页Journal of Clinical Anesthesiology

摘　　要：目的探讨咪唑安定与乳化异氟醚在大鼠麻醉中的相互作用。方法雄性SD大鼠75只随机均分为咪唑安定组(A组)、咪唑安定+乳化异氟醚组(B组)和乳化异氟醚组(C组),以夹尾是否有四肢或躯体发生逃避反射作为终点指标,采用序贯法分别测定各组药物的ED50,用Dixon-Mood法计算药物的ED50,用等辐射方法和Algebraic分析法分析药物的相互作用。结果咪唑安定和乳化异氟醚的ED50分别为(58.3±8.2)mg/kg和(1.275±0.205)ml/kg,在B组ED50分别为咪唑安定(22.5±3.2)mg/kg+乳化异氟醚(0.450±0.063)ml/kg;通过等辐射分析和代数分析显示咪唑安定同乳化异氟醚产生协同效应(P<0.01)。结论乳化异氟醚单次给药能安全的产生麻醉作用;乳化异氟醚同咪唑安定在麻醉效应上能产生协同效应。Objective To define the anesthetic interaction of emulsified isoflurane with midazolam in rats. Methods Seventy＇five male adult SD rats were randomly allocated to 3 groups with 25 rats each. The rats in group A were given midazolam only, in group B midazolam plus emulsified isoflurane and in group C emulsified isoflurane only. Movement of body or limb in response to tailclamping was measured to determine ED50 in each group by up and down sequential allocation technique. The drugs were administered via the tail vein. Midazolam was injected for 60 seconds, followed by isoflurane for 15 seconds. The interval time was 2.5 min between midazolam and emulsified isoflurane when used in combination. ED50 was calculated using Dixon-Mood method. The isobolographic and algebraic analysis were used to define the type of interaction between midazolam and emulsified isoflurane. Results The value of midazolam ED50 was （58.3±8.2） mg/kg in group A,which was greater than （22.5 ± 3.2） mg/kg in group B （P〈0.01）. The value of emulsified isoflurane ED50 was （1. 275 ± 0.205） ml/kg in group C,which was greater than （0.450±0.063） ml/kg in group B （P〈 0.01）. Conclusion A single close of emulsified isoflurane produces safe anesthetic effects. Application of emulsified isoflurane combined with midazolam produces a synergistic anesthetic effect in rats.

关 键 词：乳化异氟醚 咪唑安定 药物相互作用 

分 类 号：R614[医药卫生—麻醉学]