踝臂指数与冠状动脉粥样硬化的相关性  

The association of ankle-brachial index with coronary atherosclerosis

作　　者：杜丽根[1,2] 邱健[1] 阮云军[1] 董凤英[1] 张园[1] 洪长江[1] 马骏[1] 徐琳[1] 

机构地区：[1]广州军区广州总医院心内科,510010 [2]南方医科大学

出　　处：《实用医学杂志》2009年第6期886-888,共3页The Journal of Practical Medicine

基　　金：广东省科技计划项目(编号:2007B060401046);广东省医学科研基金资助项目(编号:A2008496)

摘　　要：目的:探讨踝臂指数(ABI)和冠状动脉粥样硬化及其病变程度的相关性。方法:选择102例冠状动脉造影的患者,依据冠脉造影的结果分为冠心病(CHD)组和对照组,CHD组根据冠脉病变的程度分为单支、双支、严重病变组。所有患者在冠脉造影前应用全自动动脉硬化测定仪测定ABI。结果:CHD组ABI明显低于对照组(1.03±0.11vs1.11±0.10,P<0.05)。冠状动脉病变程度分析中ABI在严重病变组(1.01±0.13)和双支病变组(1.03±0.09)明显低于对照组(1.11±0.10),组间比较差异有统计学意义(P<0.05)。但是ABI在严重病变组、双支病变组和单支病变组(1.06±0.08)之间,单支病变组和对照组之间差异无显著性(P>0.05)。冠状动脉造影入选患者的Gensini评分与ABI呈负相关(r=-0.3557,P<0.001)。在控制了吸烟、高血压病史、糖尿病史等多种动脉粥样硬化危险因素后,这种负相关性仍然存在(r=-0.3248,P<0.01)。结论:ABI与冠状动脉粥样硬化密切相关,在一定程度上可以反映冠脉病变的严重程度。Objective To explore the association of ankle-brachial index （ABI） with coronary atherosclerosis and its severity. Methods 102 patients were assigned to coronary heart disease group or control group according to coronary angiographic （CAG） findings. The coronary heart disease group was subdivided into single-vessel, dual-vessel, and multiple-vessel disease groups based on the severity of coronary atherosclerosis. ABI was measured in all patients by the Colin system prior to CAG. Results ABI values were significantly lower in the group with coronary heart disease than in the control group （1.03 ± 0.11 vs 1.11 ± 0.10, P 〈 0.05）. As compared with those in the control group, ABI values were markedly declined in the multiple-vessel disease group and the dual-vessel disease group （1.01 ± 0.13 vs 1.11 ± 0.10 and 1.03 ± 0.09 vs 1.11 ± 0.10, P 〈 0.05 for both comparisons）. However, there were no significant differences in ABI between the single-vessel disease group （1.06 ± 0.08） and the other three groups （P 〉 0.05 for all comparisons）. The Gensini score was negatively correlated to ABI （r =-0.3557, P 〈 0.001 ） and this relation was still existed after excluding the risk factors of atherosclerosis including smoking, hypertension, and diabetes mellitus （r = -0.3248, P 〈 0.01）. Conclusions ABI value is strongly associated with coronary atherosclerosis, signaling the severity of atherosclerosis.

关 键 词：冠状动脉疾病 踝臂指数 临床分析 患者 

分 类 号：R541.4[医药卫生—心血管疾病]