血小板膜糖蛋白GPⅡb／Ⅲa和血浆纤维蛋白原监测子痫前期及子痫的临床价值  

Clinical significance of GPⅡb/Ⅲa and FIB detection in patients with pre-eclampsia and eclampsia

作　　者：廖琪[1,2] 马晓艳[1] 崔满华[1] 郑明阳[1] 苏学金[3] 刘超[1] 李海霞[1] 

机构地区：[1]吉林大学第二临床医院妇产科,吉林长春130041 [2]齐齐哈尔医学院第五附属医院大庆龙南医院妇产科 [3]吉林大学基础教研室病理科,吉林长春130021

出　　处：《中国实用妇科与产科杂志》2009年第3期214-216,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨血小板膜糖蛋白GPⅡb/Ⅲa和血浆纤维蛋白原(FIB)对诊断和监测子痫前期和子痫的临床意义。方法2007年1月至2008年2月于吉林大学第二医院采用流式细胞术和ACL血凝仪检测子痫前期及子痫、正常孕晚期和正常未孕妇女全血中GPⅡb/Ⅲa和血浆FIB水平。结果(1)血小板膜糖蛋白GPⅡb/Ⅲa水平:分娩前子痫前期及子痫组(1.98±0.53)%比正常未孕组(0.46±0.12)%、正常孕晚期组(0.54±0.19)%均明显增高,差异有统计学意义(P<0.01);分娩前重度子痫前期及子痫组(2.60±0.63)%与正常未孕组、正常孕晚期组、轻度子痫前期组比较差异有统计学意义(P<0.01);分娩后各组之间差异均无统计学意义(P>0.05)。(2)血浆FIB水平:正常孕晚期组(4.87±0.98)g/L、轻度子痫前期组(5.89±1.25)g/L及重度子痫前期及子痫组(4.67±1.36)g/L与正常未孕组(3.09±1.10)g/L比较均明显增高,差异有统计学意义(P<0.01);重度子痫前期及子痫组比轻度子痫前期组明显降低(P<0.05),与正常孕晚期组比较差异无统计学意义(P>0.05)。结论重度子痫前期及子痫与轻度子痫前期患者比较,全血中GPⅡb/Ⅲa表达水平增高及血浆FIB水平降低,联合检测全血中GPⅡb/Ⅲa和FIB,可作为诊断监测指标。Objective To detect the clinical significance of levels of blood GPⅡb/Ⅲa and serum FIB in diagnosing and monitoring pre-eclampsia and eclampsia. Methods Fibrinogen（FIB） and GPⅡb/Ⅲa a were measured in the normal non-pregnany women, normal late-pregnancy women and pre-eclampsia and eclampsia women. The levels of FIB in the serum were detected by hemagglutinin＇ s appearance, and the GPⅡb/Ⅲa of whole blood was detected by flow cytometry, Results The levels of GPⅡb/Ⅲa in the blood ： the levels of GPⅡb/Ⅲa in pre-eclampsia/eclampsia women in pregnancy （ 1.98 ± 0. 53 ） % were higher than non-pregnancy women （ 0. 46 ±0. 12 ） % and normal late-pregnancy women （ 0. 54 ± 0. 19） % （ P 〈0. 01 ） ; Severe pre-eclampsia/eclampsia in pregnancy（ 2.60 ±0. 63 ） % was higher than non-pregnancy, normal late-pregnancy and mild pre-eclampsia（ P 〈 0. 01 ）. There was no significance between three groups in-post-delivery. The levels of FIB in serum：the levels of FIB of the normal late-pregnancy groups （4. 87 ±0. 98 ） g/L, the mild pre-eclampsia（5.89 ± 1.25） g/L and the severe pre-eclampsia/eclampsia groups （4. 67 ± 1.36） g/L were much higher than the non-pregnancy groups（ 3.09 ± 1.10 ） g/L （P 〈 0. 01 ）. The levels of FIB of severe pre-eclampsia/eclampsia groups were lower than mild pre-eclampsia （ P 〈 0.05 ）. There was no difference between severe pre-eclampsia/eclampsia and normal late-pregnancy. Conclusion The levels of GPⅡb/Ⅲa in the blood are raised and the levels of FIB in serum are lower in the severe pre-eclampsia/eclampsia and mild pre-eclampsia. It is one of important indexes to detect the GPⅡb/Ⅲa and the levels of FIB in the blood.

关 键 词：血小板膜糖蛋白 纤维蛋白原 子痫前期 子痫 

分 类 号：R71[医药卫生—妇产科学]