孕晚期注射乙肝免疫球蛋白阻断乙肝病毒宫内感染的Meta分析  

Meta-analysis on the effect of hepatitis B immunoglobulin on blocking intrauterine infection of HBV during the third-trimester

作　　者：李婷[1] 裘佳敏[1] 苗茂华[2] 苏秀娟[2] 段涛[1] 

机构地区：[1]同济大学附属上海第一妇婴保健院妇产科,上海200040 [2]上海市计划生育科学研究所

出　　处：《现代妇产科进展》2009年第3期197-200,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:综合评价孕晚期注射乙肝免疫球蛋白阻断乙肝病毒宫内感染的效果和安全性。方法:应用Revman 4.2.10软件,对计算机检索后筛选出的5项随机对照研究采用固定模型进行分析。结果:孕晚期注射HB IG组宫内感染发生率显著低于对照组[RR=0.40,95%CI(0.30,0.54)]。结论:孕晚期注射乙肝免疫球蛋白可有效地阻断乙肝病毒宫内感染。Objective：To evaluate the efficacy and security of hepatitis B immunoglo-bulin on blocking intrauterine infection of HBV during the pregnancy third-trimester.Methods：Fix and random effect meta-analysis was applied to analyse the data of 5 randomized controlled trials,using software Revman 4.2.10.Results：Babies born from pregnant women who received hepatitis B immunoglobulin during the pregnancy third-trimester had significant lower intraute-rine transmission rate than those not[RR=0.40,95%CI（0.30,0.54）].Conclusion：Injection of hepatitis B immunoglobulin during the pregnancy third-trimester can decrease intrauterine infection rate of HBV.

关 键 词：乙型肝炎免疫球蛋白 肝炎病毒 乙型 宫内感染 妊娠末期 META分析 

分 类 号：R714.251[医药卫生—妇产科学]