异位妊娠两种保守治疗方法的循证医学比较  

Comparison in evidence-based medicine of two kinds of conservative treatment for ectopic pregnancy

作　　者：刘明鸽 庞苗苗[2] 李娜[2] 安瑞芳[2] 

机构地区：[1]西安市铁路医院妇产科,陕西西安710061 [2]西安交通大学医学院第一附属医院妇产科,陕西西安710061

出　　处：《中国妇幼健康研究》2009年第2期187-189,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的比较异位妊娠两种保守治疗的方法（单用米非司酮；联用米非司酮和甲氨喋呤）。方法利用循证医学描述性系统评价方法对异位妊娠两种保守治疗进行比较。结果疗效方面：联用似可增加疗效，联用和单用相比无显著性差异（P〉0．05）；药物消散时间、住院时间、远期疗效、副作用方面：联用优于单用（P〈0．05）。结论在疗效方面，联用似可增加疗效，但不显著，联用可显著减少包块的消散时间，减少住院日，且无明显副作用增加。远期疗效较好，有较高的输卵管通畅率。未涉及再次妊娠情况。Objective To compare therapeutic effect of two kinds of conservative treatment for ectopic pregnancy （mifepristone alone and mifepristone combined with methotrexate）. Methods The descriptive methods of systematic evaluation in evidence-based medicine were used to compare therapeutic effect of two conservative treatment for ectopic pregnancy. Results （1）In therapeutic effect ： the combined use of two drugs appeared to be better than single use of mifepristone but the difference was not significant （P 〉 0.05 ） ; （2）In mass dissipation time, hospital stay, long-term therapeutic effect and adverse effect ： the combined use of two drugs was superior to single use of mifepristone （ all P 〈 0.05）. Conclusion In therapeutic effect, the combined use of mifepristone and methotrexate appears to be better than single use of mifepristone but the difference is not significant. While combined use of two drugs can significantly shorten the mass dissipation time and length of hospital stay and does not increase any side effects of the druge. Long-term therapeutic effect is better and there is a higher rate of tubal patency and also it does not induce repeated pregnancy.

关 键 词：妊娠 异位妊娠 保守治疗 甲氨喋呤 米非司酮 

分 类 号：R714.22[医药卫生—妇产科学]