肾小球足细胞骨架结构的适应性应变  

Adaptive Reaction of Actin Cytoskeleton in Podocyte Structure of Glomerulus

作　　者：康郁林[1] 朱光华[1] 何威逊[1] 

机构地区：[1]上海交通大学医学院附属儿童医院肾脏风湿科,上海200040

出　　处：《实用儿科临床杂志》2009年第5期383-385,共3页Journal of Applied Clinical Pediatrics

摘　　要：肾小球足细胞肌动蛋白骨架是一个复杂的网络结构,其形态结构的稳定性与裂孔隔膜、足突顶端、足突基底等区域的相关蛋白分子密切相关,面对外力作用,在RhoA/Rho激酶信号通路、瞬时受体电位阳离子通道蛋白6(TRPC6)等参与下,足细胞骨架能在一定范围内进行适应性应变,以维护肾小球的正常滤过功能。Actin cytoskeleton in podocyte is a complicated network structure,and the stability of this structure depend on many proteins which located in slit diaphragm,the apical membrane domain and the basal membrane domain with the stimulus of mechanical stress,the actin cytoskeleton can be adaptive regulated to maintain the normal function of glomerulus,and several signal pathways involve in the process,such as RhoA/Rho kinase signal pathway and TRPC6.

关 键 词：足细胞骨架 裂孔隔膜 RhoA/Rho激酶信号通路 P38MAP激酶 

分 类 号：R692[医药卫生—泌尿科学]