超重肥胖儿童代谢综合征组分的因子分析  

Factor Analyses of Metabolic Syndrome Components in Chinese Overweight and Obese Children

作　　者：吴双胜[1] 王海俊[2] 马军[1] 王莹[1] 

机构地区：[1]北京大学公共卫生学院/儿童青少年卫生研究所,北京100191 [2]北京大学公共卫生学院妇女与儿童青少年卫生学系

出　　处：《中国学校卫生》2009年第3期204-206,共3页Chinese Journal of School Health

基　　金：国家自然科学基金资助项目(编号:30700668);高等学校博士学科点专项科研基金资助课题(编号:20070001811);国家体育总局群体招标项目(编号:06134)

摘　　要：目的分析超重肥胖儿童代谢综合征(MS)各组分的聚集特征,探索儿童代谢综合征的病理生理机制。方法研究对象来自前期工作收集的2批样本,为北京市835名14,15岁超重肥胖儿童,其中样本1有93人(超重62人,肥胖31人)、样本2有742人(超重371人,肥胖371人)。先对样本1中超重和肥胖儿童代谢综合征的组分(包括体质指数、腰围、血糖、血脂、血压)进行因子分析,后对样本2进行因子分析用以验证和确认分析结果。结果超重儿童MS组分共提取4个因子,脂代谢因子(LDL-C,TC,TG,HDL-C)、血压因子(SBP,DBP)、肥胖因子(WC,BM I)和糖代谢因子(FPG,HDL-C),累积方差贡献率达到77.44%;肥胖儿童MS组分共提取3个因子,肥胖-血压因子(WC,BM I,SBP,DBP)、脂代谢因子(LDL-C,TC,TG,HDL-C)和糖代谢因子(FPG),累积方差贡献率达到69.84%。结论儿童MS的病理生理机制复杂,任何一个因子都不能单独解释MS的全部变量。Objective To identify the clustering characteristics of metabolic syndrome （MS） components in overweight and obese children, and to explore the mechanism of pediatric metabolic syndrome. Methods Factor analyses were applied to identify the clustering characteristics of MS in a school-based population of 835 children aged 14 -15 years in Beijing, including 93 exploratory samples （62 overweight, 31 obesity） and 742 validation samples （371 overweight, 371 obesity）. The following MS components were considered： body mass index, waist circumference, fasting glucose, total cholesterol, triglycerides, low and high density lipoprotein, systolic and diastolic pressure. Results Principal component factor analyses revealed four factors in overweight group ： lipid-metabolic （LDL - C, TC, TG, HDL - C ） , blood pressure （SBP, DBP）, adiposity （WC, BMI）, carbohydrate-metabolic （ FPG, HDL - C） that cumulatively explained 77.44% of the observed variance of metabolic syndrome; and three factors in obesity group： adiposity-blood pressure （WC, BMI, SBP, DBP）, lipid-metabolic （LDL- C, TC, TG, HDL- C）, carbohydrate-metabolic （FPG） that cumulatively explained 69.84% of the observed variance of metabolic syndrome. Conclusion MS pathological mechanism in children is complicated, more than one physiological mechanism account for the clustering of risk factors of metabolic syndrome in Chinese children.

关 键 词：超重 肥胖症 代谢综合征X 人体质量指数 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R589.2[医药卫生—公共卫生与预防医学]