氟化氨银局部应用防龋抑制口腔内变形链球菌效果观察  

Impact of Topical Use of Silver Diamine Fluoride on Streptococcus Mutans Inhibition

作　　者：刘学军[1] 张晶[1] 薛晶[1] 岳阳丽[1] 吉亚丽[1] 

机构地区：[1]郑州大学口腔医学院,河南450052

出　　处：《中国学校卫生》2009年第3期245-246,共2页Chinese Journal of School Health

摘　　要：目的探索氟化氨银局部应用对儿童口腔内变形链球菌的抑制效果,为开展儿童口腔保健、预防疾病提供依据。方法将40名高龋儿童随机分成氟化氨银干预组、窝沟封闭组、联合干预组以及对照组,取其基线和干预后1周、4周、8周的唾液样本,稀释后接种于培养变形链球菌的轻唾-杆菌肽琼脂(mitis salivarius bacitricin agar,MSBA)选择培养基,观察变形链球菌检出情况并记录每毫升菌落数。结果氟化氨银组与窝沟封闭组和对照组、联合干预组与窝沟封闭组及对照组比较差异均有统计学意义(P值均<0.05),窝沟封闭组与对照组比较差异无统计学意义(P>0.05),氟化氨银组与联合干预组比较差异无统计学意义(P>0.05)。结论氟化氨银有在短期内抑制口腔内变形链球菌生长的作用。Objective To study the inhibition effects of silver diamine fluoride on oral streptococcus mutans in ehildren＇s saliva, and to provide bases for children＇s oral health. Methods Forty children with high level of dmf were divided into four groups randomly, the treatments were as following： topical use of silver diamine fluoride（group A）, pit and fissure sealants（group B）, topical use of silver diamine fluoride ＋ pit and fissure sealants （ group C ） and control group. The salivary sample of all the subjects were collected for four times： before treatment （baseline）, a week after treatment, four weeks after treatment, eight weeks after treatment. The samples were diluted and inoculated in the selective Mitis Salivarius Bacitricin Agar, the colony CFU/mL was recorded. Results There was significant difference between group A and group B or control group, group C and group B and control group （P〈0.05）. There was no significant difference between group B and the control group （P〉0.05）. Conclusion Silver diamine fluoride is effective in reducing the growth of streptococcus mutans in children＇s saliva.

关 键 词：龋齿 氟化物 外用 链球菌 口腔 投药 局部 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R780.1[医药卫生—公共卫生与预防医学]