含镁羟基磷灰石、磷酸三钙复合生物陶瓷涂层的研究  

Sol-gel derived magnesium HA/β-Ca_3(PO_4)_2 biphasic bioceramic coatings

作　　者：齐国超[1] 刘春明[1] 

机构地区：[1]东北大学材料与冶金学院,沈阳110004

出　　处：《材料与冶金学报》2009年第1期47-50,共4页Journal of Materials and Metallurgy

基　　金：教育部跨世纪优秀人才计划项目

摘　　要：通过溶胶凝胶法在钛合金基体上合成了含镁羟基磷灰石/β-磷酸三钙陶瓷复合涂层.研究表明,羟基磷灰石相与β-磷酸三钙相共同存在于600℃烧结的复合涂层中.X射线光电子能谱分析显示,镁离子已合成到涂层之中.在模拟体液中,在复合涂层表面沉积出了较为明显的新生类骨层.使用MG63细胞进行培养试验,结果显示涂层具有良好的细胞亲和性.试验结果表明:含镁羟基磷灰石/β-磷酸三钙复合涂层具有良好的生物活性,有望在医疗实践中作为人工骨质材料得到广泛应用.Magnesium containing hydroxyapatite （HA） /β- Ca3 （PO4 ）2 （β- TCP） biphasic coating is synthesized with a sol - gel method. It is shown from the study that both phases from HA and β- TCP are derived after sintered at 600℃. X- ray photoelectron spectroscopy （XPS） analysis shows that magnesium ion is well incorporated in the coating. New dense apatite layer forms on the surface of magnesium containing HA/β - TCP coating after soaking in simulated body fluid （SBF）. MG63 cells are used to evaluate the in vitro response and the results show that the coating has good bioresponse with the cells. The study shows that magnesium containing HA/β - TCP coating has good bioresponse which gives expectations for the future medical applications,

关 键 词：生物陶瓷 溶胶凝胶法 羟基磷灰石 Β-磷酸三钙 模拟体液 

分 类 号：R318.08[医药卫生—生物医学工程]